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Technical Data Sheet Motesanib
Compound Information
Product Name:
Motesanib
CAS No.:
453562-69-1
Molecular Formula:
C22H23N5O
Molecular Weight:
373.45
Storage:
Powder -20°C 3 years; 4°C 2 years
In solvent -80°C 6 months; -20°C 1 month
In solvent -80°C 6 months; -20°C 1 month
Revision Date:
2026-04-15
Analytical Information
| Tests | Specifications |
|---|---|
| Description | Motesanib (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret. |
| Form | White powder solid. |
| Color | Pale Yellow |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Purity | Shows >98% purity |
| ¹H NMR | Pass test |
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