| Identification | More | [Name]
Sodium orthovanadate | [CAS]
13721-39-6 | [Synonyms]
DECAVANDATE
SODIUM ORTHOVANADATE
SODIUM ORTHOVANADATE(V)
SODIUM O-VANADATE
SODIUM VANADATE
SODIUM VANADATE, ORTHO
(beta-4)-vanadate(vo43-trisodium
Sodiumorthovanadate,dodecahyd
sodiumtetraoxovanadate(3-)
sodiumvanadate(v)(na3vo4)
sodiumvanadiumoxide(na3vo4)
trisodium(t-4)-vanadate(vo4(3-)
trisodium,(T-4)-Vanadate
trisodiumorthovanadate
trisodiumvanadate
vanadic(ii)acid,trisodiumsalt
Vanadicacidtrisodiumsalt
Sodium orthovanadate dodecahydrate
sodium tetraoxovanadate
trisodium tetraoxovanadate | [EINECS(EC#)]
237-287-9 | [Molecular Formula]
Na3O4V | [MDL Number]
MFCD00003511 | [Molecular Weight]
183.91 | [MOL File]
13721-39-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [RIDADR ]
UN3285 | [WGK Germany ]
3
| [RTECS ]
YW1120000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
28419030 | [Safety Profile]
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of VOx and NazO. See also VANADIUM COMPOUNDS. |
| Hazard Information | Back Directory | [Hazard]
Poison by ingestion.
| [Chemical Properties]
white to off-white powder | [Uses]
Sodium orthovanadate (Na3VO4) can be used as a metal precursor in the synthesis of:
- Vanadium-MCM-48 (V-MCM-48) by anion-exchange method. V-MCM-48 is used as a catalyst in oxidation of styrene to benzaldehyde.
- Nanorods of vanadium oxide particles by glycothermal method.
- Yttrium vanadate (YVO4) doped with colloidal europium.
| [Uses]
Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. | [Uses]
Sodium Orthovanadate is an inhibitor of several phosphatases and kinases. General inhibitor of tyrosine phosphatases, a large family of enzymes that catalyze the removal of phosphate groups from tyrosine residues. | [Definition]
ChEBI: Trisodium vanadate is an inorganic sodium salt of formula Na3VO4 containing the tetrahedral VO4(3-) It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, a radiation protective agent, an apoptosis inducer and an antineoplastic agent. It contains a vanadate(3-). | [Preparation]
Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:
V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2O
The salt features tetrahedral VO3-4 anion centers linked to octahedral Na+ cation sites. | [Biological Activity]
Inhibitor of protein tyrosine phosphatases, alkaline phosphatases and ATPases. | [Biochem/physiol Actions]
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25 | [storage]
Store at RT |
|
|