ChemicalBook--->CAS DataBase List--->19847-10-0

19847-10-0

19847-10-0 Structure

19847-10-0 Structure
IdentificationMore
[Name]

2-PYRAZINECARBONYL CHLORIDE
[CAS]

19847-10-0
[Synonyms]

2-PYRAZINECARBONYL CHLORIDE
ASINEX-REAG BAS 07703829
PYRAZINE-2-CARBONYL CHLORIDE
PYRAZINE-2-CARBOXYLIC ACID CHLORIDE
TIMTEC-BB SBB010290
pyrazinecarbonyl chloride
2-PYRAZINECARBONYL CHLORIDE: TECH.
[EINECS(EC#)]

243-367-4
[Molecular Formula]

C5H3ClN2O
[MDL Number]

MFCD00792886
[Molecular Weight]

142.54
[MOL File]

19847-10-0.mol
Chemical PropertiesBack Directory
[Melting point ]

41°C
[Boiling point ]

214.5±20.0 °C(Predicted)
[density ]

1.393±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[pka]

-2.50±0.10(Predicted)
[Water Solubility ]

Reacts with water.
[Sensitive ]

Moisture Sensitive
[CAS DataBase Reference]

19847-10-0(CAS DataBase Reference)
Safety DataBack Directory
[Risk Statements ]

R34:Causes burns.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

3265
[HazardClass ]

8
[PackingGroup ]

II
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Thionyl chloride-->Benzene-->Sulfuryl chloride-->2-Pyrazinecarboxylic acid
[Preparation Products]

(S)-3-PHENYL-2-[(PYRAZIN-2-YLCARBONYL)AMINO] PROPANOIC ACID
Hazard InformationBack Directory
[Uses]

2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

2-pyrazinecarbonyl chloride(19847-10-0)
[Alfa Aesar]

Pyrazine-2-carbonyl chloride(19847-10-0)
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