| Identification | More | [Name]
5-Chloro-1-indanone | [CAS]
42348-86-7 | [Synonyms]
5-CHLORO-1-INDANONE
5-CHLOROINDAN-1-INDANONE
5-CHLOROINDAN-1-ONE
1H-Inden-1-one, 5-chloro-2,3-dihydro-
1-Indanone, 5-chloro-
5-Chloro-2,3-dihydro-1H-inden-1-one
5-Chloro-1-indanone,99%
5-Chloro Indanone
5-chloro-2,3-dihydroinden-1-one | [EINECS(EC#)]
610-016-5 | [Molecular Formula]
C9H7ClO | [MDL Number]
MFCD00041456 | [Molecular Weight]
166.6 | [MOL File]
42348-86-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29147000 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystal | [Uses]
5-Chloro-1-indanone is the important intermediate of du pont company's new varieties of pesticides indoxacarb (popular name: indoxacarb), is also a kind of important medicine intermediate simultaneously.
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types.
5-Chloro-1-indanone may be used as starting reagent for the preparation of 5-chloro-2-methoxycarbonyl-1-indanone. It may be used for the preparation of important biomedical compounds such as anticonvulsants, anticholinergics and diarylsulfonylureas, having potential activity against solid tumors. | [Preparation]
3-chlorobenzaldehyde as raw material first reacts with propionic acid to prepare 3-chloro-phenylpropionic acid, which is then subjected to Friedel-Crafts acylation reaction to prepare 5-chloro-1-indanone. Organic solvents of formic acid diethylamine participate in the first step, and the reaction temperature is 20-150℃. An organic solvent of methylene chloride and a catalyst of zinc chloride participate in the second step, and the reaction temperature is -10 to 80 ℃.
Synthetic method of 5-chloro-1-indanone | [General Description]
5-Chloro-1-indanone is a 5-halo-1-indanone. It participates in the Irie′s synthesis of substituted pyridines. 5-Chloro-1-indanone has a stable triclinic crystal structure and has intermolecular forces of C-H...O, C-H...Π, CO...Cl and Π...Π types. |
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