| Identification | More | [Name]
5-Nitroisatin | [CAS]
611-09-6 | [Synonyms]
5-NITRO-1H-INDOLE-2,3-DIONE
5-NITROINDOLE-2,3-DIONE
5-NITROISATIN
AKOS B022561
AKOS BBS-00006405
LABOTEST-BB LT00146672
1H-Indole-2,3-dione,5-nitro-
5-nitro-1h-indole-3-dione
5-nitro-indole-3-dione
5-nitro-isati
Indole-2,3-dione, 5-nitro-
Isatin, 5-nitro-
2,3-dihydro-5-nitroindole-2,3-dione
Nitroisatin
5-Nitroisatin,98+%
5-Nitro-2,3-indolinedione
5-Nitroindoline-2,3-dione
5-Nitroisatin (5-Nitro-1H-indole-2,3-dione) | [EINECS(EC#)]
210-252-5 | [Molecular Formula]
C8H4N2O4 | [MDL Number]
MFCD00005720 | [Molecular Weight]
192.13 | [MOL File]
611-09-6.mol |
| Chemical Properties | Back Directory | [Appearance]
orange-yellow to orange crystalline powder | [Melting point ]
251 °C (dec.) (lit.) | [Boiling point ]
328.09°C (rough estimate) | [density ]
1.5513 (rough estimate) | [refractive index ]
1.4900 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Crystalline Powder | [pka]
8.06±0.20(Predicted) | [color ]
Orange-yellow to orange | [BRN ]
180223 | [InChIKey]
UNMYHYODJHKLOC-UHFFFAOYSA-N | [CAS DataBase Reference]
611-09-6(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-indole-2,3-dione, 5-nitro-(611-09-6) |
| Questions And Answer | Back Directory | [Preparation]
Isatin 30 (14.7 g, 0.1 mol) was added to conc. H2SO4 (121 ml) cooled to 0 ºC in an ice-salt bath. Fuming HNO3 (4.2 ml) was added to this, drop by drop, in such a way that temperature should not rise above 5 ºC. The reaction mixture was allowed to stand for about 30 minutes and then poured over crushed ice (500 g). A yellow precipitate separated immediately. The 5-Nitroisatin was filtered and washed with water and air dried to a constant weight (15 g). Yield : 85% |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R40:Limited evidence of a carcinogenic effect.
R68:Possible risk of irreversible effects.
R22:Harmful if swallowed. | [Safety Statements ]
S7:Keep container tightly closed .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
NL7970000
| [HazardClass ]
IRRITANT | [HS Code ]
29337900 |
| Hazard Information | Back Directory | [Chemical Properties]
orange-yellow to orange crystalline powder | [Uses]
Reactant for preparation of:
- Potential antibacterial and antifungal agents
- spiro[indole-thiazolidinones] as a medicinally important scaffold
- Potential antimycobacterial agents
- Anticonvulsant agents
- Inhibitors of human transglutaminase 2
- Anthelmintic agents
- Anti-human immunodeficiency virus (HIV) agents
- Antimicrobial agents
- Potential antitubercular agents
- Inhibitors of acetylcholinesterase
| [Definition]
ChEBI: 5-Nitroisatin is a member of indoles. It has a role as an anticoronaviral agent. |
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