| Identification | More | [Name]
Tetramethylguanidine | [CAS]
80-70-6 | [Synonyms]
1,1,3,3-TETRAMETHYLGUANIDINE
N,N-1,1,3,3-TETRAMETHYLGUANIDINE
N,N,N',N'-TETRAMETHYLGUANIDINE
TETRAMETHYL GUANIDINE
1,1,3,3-Tetramethylguayyniaine
Guanidine, 1,1,3,3-tetramethyl-
Guanidine, N,N,N',N'-tetramethyl-
n,n,n’,n’-tetramethyl-guanidin
N,N’-Tetramethylguanidine
1,1,3,3-Tetramethyl Guanidine (TMG)
1,1,3,3-Tetramethylgyanidine, 97+%
1,1,3,3-Tetramethylguanidine,99%
N,N,N,N-Tetramethy1 Guanidine
1,1,3,3-Tetramethylguanidin
TMG
N1,N1,N3,N3-Tetramethylguanidine
N,N,N',N'-Tetramethyl-α-iminomethanediamine
α,α-Bis(dimethylamino)methanimine | [EINECS(EC#)]
201-302-7 | [Molecular Formula]
C5H13N3 | [MDL Number]
MFCD00008323 | [Molecular Weight]
115.18 | [MOL File]
80-70-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Liquid | [Melting point ]
-30 °C
| [Boiling point ]
162-163 °C (lit.) | [density ]
0.918 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.2 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.469
| [Fp ]
140 °F
| [storage temp. ]
2-8°C
| [solubility ]
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
15.20±0.70(Predicted) | [color ]
APHA: ≤150 | [Odor]
mild ammoniacal odor | [PH]
12.7 (10g/l, H2O, 25℃) | [Relative polarity]
5.5 | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive. | [explosive limit]
1.0-7.5%(V) | [Water Solubility ]
miscible | [Sensitive ]
Air Sensitive | [Usage]
Tetramethylguanidine (TMG) is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries. Product Data Sheet | [BRN ]
969608 | [Dielectric constant]
23.100000000000001 | [InChIKey]
KYVBNYUBXIEUFW-UHFFFAOYSA-N | [LogP]
-0.49 at 20℃ | [CAS DataBase Reference]
80-70-6(CAS DataBase Reference) | [NIST Chemistry Reference]
N,N,N',N'-Tetramethylguanidine(80-70-6) | [EPA Substance Registry System]
80-70-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R20/22:Harmful by inhalation and if swallowed .
R10:Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2920 8/PG 2
| [WGK Germany ]
1
| [F ]
9-23 | [Autoignition Temperature]
222 °C | [Hazard Note ]
Harmful/Corrosive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29252000 | [Toxicity]
LD50 orally in Rabbit: 835 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Liquid | [Uses]
1,1,3,3-Tetaramethylguanidine is used as a strong, non-nucleophilic base for alkylations in organic synthesis. 1,1,3,3-Tetramethylguanidine is an efficient and selective catalyst for the benzoylation
of alcohols. | [Uses]
Base employed in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines. | [Uses]
Tetramethylguanidine (TMG) is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries. Product Data Sheet | [Flammability and Explosibility]
Flammable | [Synthesis]
Prepared from cyanogen chloride and dimethylamine in a 1 : 2 molar
ratio, TMG is used as a polyurethane foam
catalyst, in the preparation of pigments for color
photography, and in steroid synthesis. | [Purification Methods]
Reflux it over granulated BaO, then fractionally distil it. Protect it from CO2. [Beilstein 4 IV 227.] |
| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
1,1,3,3-Tetramethylguanidine, 99%(80-70-6) | [Alfa Aesar]
1,1,3,3-Tetramethylguanidine, 99%(80-70-6) | [Sigma Aldrich]
80-70-6(sigmaaldrich) | [TCI AMERICA]
1,1,3,3-Tetramethylguanidine,>99.0%(GC)(80-70-6) |
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