645-43-2
中文名称
单硫酸胍乙啶
英文名称
GUANETHIDINE SULFATE
CAS
645-43-2
EINECS 编号
211-442-0
分子式
C10H24N4O4S
MDL 编号
MFCD00035403
分子量
296.39
MOL 文件
645-43-2.mol
更新日期
2024/06/02 22:32:22
645-43-2 结构式
基本信息
中文别名
单硫酸胍乙啶硫酸胍乙啶
英文别名
GUANETHIDINE MONOSULFATEGUANETHIDINE MONOSULFATE (1:1)
GUANETHIDINE SULFATE
(2-(hexahydro-1(2h)-azocinyl)ethyl)guanidinehydrogensulfate
(2-(hexahydro-1(2h)-azocinyl)ethyl)-guanidinsulfate(1:1)
2-(octahydro-1-azocinyl)ethylguanidinesulphate
n-(2-guanidinoethyl)heptamethyleniminesulfate
Guanethidine Sulphae
[2-(hexahydro-(2H)-azocin-1-yl)ethyl]guanidinium sulphate
GUANETHIDINEMONOSULFATE,USP
1-(2-Guanidinoethyl)octahydroazocine
2-(1-Azacyclooctyl)ethylguanidine monosulfate
所属类别
原料药:抗高血压病药物理化学性质
熔点276-281 °C
储存条件2-8°C
溶解度易溶于水,几乎不溶于乙醇(96%)
形态固体
颜色白色至灰白色
稳定性吸湿性
InChIKeyYUFWAVFNITUSHI-UHFFFAOYSA-N
应用领域
用途1
为肾上腺.素能神经阻断剂。其作用是干扰交感神经末梢去甲肾上腺.素的释放,亦耗竭去甲肾上腺.素的贮存,因而当肾上腺.素能神经冲动达到末梢时,不再有足量的介质进行传递,交感神经活动降低,血压下降,其降压作用较强而持久。主要用于中度和重度舒张压高的高血压、较顽固的高血压及肾性高血压等。单硫酸胍乙啶价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-B0800 | 单硫酸胍乙啶 Guanethidine sulfate | 645-43-2 | 10mM * 1mLin Water | 550元 |
2024/04/30 | S5496 | 单硫酸胍乙啶 Guanethidine Monosulfate | 645-43-2 | 25mg | 794.83元 |
2024/04/30 | HY-B0800 | 单硫酸胍乙啶 Guanethidine sulfate | 645-43-2 | 500 mg | 1000元 |
常见问题列表
生物活性
Guanethidine sulfate (Guanethidine monosulfate) 是一种抗高血压药。Guanethidine sulfate 也是一种肾上腺素能神经元阻滞药,通过神经元胺载体进入去甲肾上腺素能神经末梢。体内研究
Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes.
Animal Model: | Male Wistar rats (approximately 200 g) |
Dosage: | 5 mg/kg or 40 mg/kg |
Administration: | Intraperitoneal injection; daily; for 4, 8, 14, or 28 days |
Result: | Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg. |