鏈菌鹼

生物活性靶点体外研究

鏈菌鹼

CAS号:: 7229-50-7

英文名:: Streptolydigin

英文别名:: portamycin;Streptolydigin;Antibiotic D-45;2-Pyrrolidineacetamide, 4-(2E,4E,6R)-6-(1R,2R,3R,4S,5R)-1,4-dimethylspiro2,9-dioxabicyclo3.3.1non-6-ene-8,2-oxiran-3-yl-1-hydroxy-4-methyl-2,4-heptadienylidene-N,.alpha.-dimethyl-3,5-dioxo-1-(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl-, (.alpha;2-Pyrrolidineacetamide, 4-[(2E,4E,6R)-6-[(1R,2'R,3R,4S,5R)-1,4-dimethylspiro[2,9-dioxabicyclo[3.3.1]non-6-ene-8,2'-oxiran]-3-yl]-1-hydroxy-4-methyl-2,4-heptadien-1-ylidene]-N,α-dimethyl-3,5-dioxo-1-[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-, (αS,2S,4E)-

中文名:: 鏈菌鹼

中文别名:: 链菌碱;門黴素;鏈菌鹼;链霉溶菌素;利迪链菌素;化合物 T16945

CBNumber:: CB11075275

分子式:: C32H46N2O9

分子量:: 602.72

MOL File:: 7229-50-7.mol

化学性质安全信息用途供应商 10

鏈菌鹼化学性质

熔点:: 147-148°

比旋光度:: D25 -93° (c = 1.6 in chloroform)

沸点:: 659.54°C (rough estimate)

密度:: 1.1852 (rough estimate)

折射率:: 1.6260 (estimate)

酸度系数(pKa):: 4.50±1.00(Predicted)

安全信息

毒性:	LD50 i.p. in mice: 533 mg/kg (DeBoer)

鏈菌鹼性质、用途与生产工艺

生物活性

Streptolydigin (Portamycin) 是一种 3-乙酰基四酸抗生素，是一种有效的细菌 RNA 聚合酶 (bacterial RNA polymerase) 抑制剂，Ki 为 18 μM，Kd 为 15 μM。Streptolydigin 通过与 RNA 聚合酶结合来抑制 RNA 合成 (RNA synthesis)，但不抑制真核生物 RNA 聚合酶。Streptolydigin 具有强大的抗菌活性，特别是对厌氧菌和一些革兰氏阳性需氧菌。

靶点

Ki: 18 μM (Bacterial RNA polymerase)
Kd: 15 μM (Bacterial RNA polymerase)

体外研究

The antibiotic Streptolydigin (Stl) is a derivative of 3-acetyltetramic acid. Binding of Streptolydigin to RNA polymerase strictly depends on a noncatalytic magnesium ion which is likely chelated by the aspartate of the bridge helix of the active center.
Streptolydigin inhibits T. thermophilus RNA polymerase with a K _i of 1.8 μM.
Streptolydigin (Stl) inhibits initiation, elongation, and pyrophosphorolysis by bacterial RNA polymerase. Streptolydigin interacts with three structural elements within RNAP: the Stl pocket, the bridge helix, and the trigger-loop region. The Streptolydigin streptolol moiety interacts with the Streptolydigin pocket and bridge helix, and the Streptolydigin tetramic-acid moiety interacts with the trigger-loop region.

鏈菌鹼上下游产品信息

上游原料

下游产品

鏈菌鹼生产厂家

全球有 10家供应商鏈菌鹼国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	美国	14059	65
武汉天植生物技术有限公司	18607101326 15172504745	aileen@chemfaces.com	中国	7059	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	美国	8449	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
四川百奥克睿生物科技有限公司	28-85433893	info@biocrick.com	中国	4988	58
成都超九八生物科技有限公司	13348960310 13348960310	3003867561@qq.com	中国	9946	58
常州孚睿斯生物科技有限公司	0519-85524369	3477467573@qq.com	中国	8618	58
杭州摩库生物医药科技有限公司	+86-057181025280; +8617767106207	sales@molcore.com	中国	49739	58

7229-50-7, 鏈菌鹼相关搜索:

(R)-(+)-1,2-环氧基-9-癸烯 1,5-二甲基-2-吡咯烷酮 3-吡咯烷酮 N-(丁氧基甲基)-2-甲基-2-丙烯酰胺 2,4-癸二烯-1-醇 N-(N-丁氧基甲基)丙烯酰胺环氧丙烯醛缩二乙醇 N-甲基-2-(2-氨乙基)-吡咯烷鏈菌鹼 N-(3-氨基丙基)甲基丙烯酸盐盐酸盐 N-甲基-3-吡咯烷酮反式-8-反式-10-十二碳二烯-1-醇已二酰二胺 2,4-壬二烯-1-醇

C32H44N2O9
利迪链菌素
化合物 T16945
链霉溶菌素
链菌碱
門黴素
鏈菌鹼
7229-50-7
2-Pyrrolidineacetamide, 4-[(2E,4E,6R)-6-[(1R,2'R,3R,4S,5R)-1,4-dimethylspiro[2,9-dioxabicyclo[3.3.1]non-6-ene-8,2'-oxiran]-3-yl]-1-hydroxy-4-methyl-2,4-heptadien-1-ylidene]-N,α-dimethyl-3,5-dioxo-1-[(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]-, (αS,2S,4E)-
Antibiotic D-45
portamycin
2-Pyrrolidineacetamide, 4-(2E,4E,6R)-6-(1R,2R,3R,4S,5R)-1,4-dimethylspiro2,9-dioxabicyclo3.3.1non-6-ene-8,2-oxiran-3-yl-1-hydroxy-4-methyl-2,4-heptadienylidene-N,.alpha.-dimethyl-3,5-dioxo-1-(2S,5S,6S)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl-, (.alpha
Streptolydigin

鏈菌鹼