匹伏普利
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- CAS号:
- 81045-50-3
- 英文名:
- Pivopril
- 英文别名:
- Pivopril;RHC 3659(S);N-Cyclopentyl-N-[(S)-3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine;Glycine, N-cyclopentyl-N-[(2S)-3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]-
- 中文名:
- 匹伏普利
- 中文别名:
- 匹伏普利;化合物 T16544
- CBNumber:
- CB21116119
- 分子式:
- C16H27NO4S
- 分子量:
- 329.45
- MOL File:
- 81045-50-3.mol
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匹伏普利化学性质
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沸点:
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490.4±38.0 °C(Predicted)
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密度:
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1.16±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.49±0.10(Predicted)
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匹伏普利性质、用途与生产工艺
Pivalopril 是一种新的口服活性的血管紧张素转换酶 (ACE) 抑制剂。
Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED
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for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED
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is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent.
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81045-50-3, 匹伏普利 相关搜索:
- C16H27NO4S
- 化合物 T16544
- 匹伏普利
- 81045-50-3
- Glycine, N-cyclopentyl-N-[(2S)-3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]-
- RHC 3659(S)
- N-Cyclopentyl-N-[(S)-3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]glycine
- Pivopril