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氟齐胺

氟齐胺, 76263-13-3, 结构式
氟齐胺
CAS号:
76263-13-3
英文名:
Fluzinamide
英文别名:
AHR-8559;Fluzinamide;3-[3-(Trifluoromethyl)phenoxy]-1-(methylcarbamoyl)azetidine;1-Azetidinecarboxamide, N-methyl-3-[3-(trifluoromethyl)phenoxy]-
中文名:
氟齐胺
中文别名:
氟齐胺;氟泽酰胺;化合物 T15302
CBNumber:
CB21178803
分子式:
C12H13F3N2O2
分子量:
274.24
MOL File:
76263-13-3.mol

氟齐胺化学性质

沸点:
415.7±45.0 °C(Predicted)
密度:
1.337±0.06 g/cm3(Predicted)
储存条件:
Store at -20°C
溶解度:
Soluble in DMSO
酸度系数(pKa):
14.24±0.40(Predicted)
安全信息

氟齐胺性质、用途与生产工艺

生物活性

Fluzinamide 是一种有效的抗癫痫剂。

体内研究

Fluzinamide, an antiepileptic agent effective against partial seizures, is metabolized extensively in mice, rats and dogs.The anticonvulsant properties of Fluzinamide (AHR-8559) are evaluated in the kindled amygdaloid seizure model in rats. Fluzinamide significantly attenuates afterdischarge durations and the severity of the accompanying convulsive responses in previously kindled rats at doses that does not cause sedation or ataxia. After acute intraperitoneal injections, the maximum anticonvulsant effectiveness against suprathreshold (400 μA) stimulation is seen at 30 min. Fluzinamide (10-80 mg/kg i.p.) is also evaluated in kindled rats using threshold (20 μA increments) seizures. Low doses of Fluzinamide significantly elevate seizure threshold and reduce both elicited after discharge durations and seizure severity. When administered daily during kindling acquisition, Fluzinamide (20 and 40 mg/kg i.p.) significantly increases the number of trials necessary to complete kindling. The duration and the severity of the responses induced by stimulations during the acquisition period are reduced.

氟齐胺 上下游产品信息

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氟齐胺 生产厂家

全球有 7家供应商   氟齐胺国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海一飞生物科技有限公司 021-65675885 18964387627 info@efebio.com 中国 9709 58
深圳市丽晶生化科技有限公司 0755-0755-85201366 18938635012 sales@regentsciences.com 中国 9293 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
天津普西唐生物医药科技有限公司 010-60605840 psaitong@jm-bio.com 中国 29778 58
TargetMol中国(陶术生物) 4008200310 marketing@tsbiochem.com 中国 24018 58
 

76263-13-3, 氟齐胺 相关搜索:

  • 化合物 T15302
  • 氟泽酰胺
  • 氟齐胺
  • 76263-13-3
  • 1-Azetidinecarboxamide, N-methyl-3-[3-(trifluoromethyl)phenoxy]-
  • AHR-8559
  • 3-[3-(Trifluoromethyl)phenoxy]-1-(methylcarbamoyl)azetidine
  • Fluzinamide
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