依普西隆
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- CAS号:
- 95847-70-4
- 英文名:
- Ipsapirone
- 英文别名:
- Isapirone;IPSAPIRONE;Benzeneethanamine,5-chloro-α-methyl-;1,2-benzisothiazol-3(2h)-one,2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-,1,;2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide;2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE;1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, 1,1-dioxide
- 中文名:
- 依普西隆
- 中文别名:
- 依普西隆;化合物 T22871;IPSAPIRONE,5-HT1激动剂;2-[4-[4-(2-嘧啶基)-1-哌嗪基]丁基]-1,2-苯并异噻唑-3(2H)-酮-1,1-二氧化物
- CBNumber:
- CB2254702
- 分子式:
- C19H23N5O3S
- 分子量:
- 401.48
- MOL File:
- 95847-70-4.mol
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依普西隆化学性质
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熔点:
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137-138°
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沸点:
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629.8±65.0 °C(Predicted)
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密度:
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1.345±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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Soluble to 10 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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7.69±0.10(Predicted)
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依普西隆性质、用途与生产工艺
Ipsapirone (TVX Q 7821)，是具有抗焦虑活性的化合物，是 5-HT1A 受体的部分激动剂，也表现出 5-HT1A 受体的拮抗作用，并且只在高剂量时，对 5-HT2 和α1 肾上腺素能表现出抑制作用。
Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats.
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃.
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Animal Model:
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Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g).
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Dosage:
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5 and 10 mg/kg.
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Administration:
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IP 30 min before 8-OH-DPAT and 5-MeODMT injections.
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Result:
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Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).
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依普西隆
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-19686 | 依普西隆
Ipsapirone | 95847-70-4 | 5mg | 800元 |
| 2024/04/30 | HY-19686 | Ipsapirone | | 10 mg | 1200元 |
95847-70-4, 依普西隆 相关搜索:
- Serotonin receptor
- 合成有机化合物配体
- C19H23N5O3S
- IPSAPIRONE,5-HT1激动剂
- 化合物 T22871
- 依普西隆
- 2-[4-[4-(2-嘧啶基)-1-哌嗪基]丁基]-1,2-苯并异噻唑-3(2H)-酮-1,1-二氧化物
- 95847-70-4
- 1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, 1,1-dioxide
- Benzeneethanamine,5-chloro-α-methyl-
- 2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide
- Isapirone
- 1,2-benzisothiazol-3(2h)-one,2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-,1,
- 2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE
- IPSAPIRONE