盐酸咪唑克生
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- CAS号:
- 79944-56-2
- 英文名:
- IDAZOXAN HYDROCHLORIDE
- 英文别名:
- RX 781094A;IdazoxanHCl;Idazoxan hydrochlori;IDAZOXAN HYDROCHLORIDE;(+/-)-Idazoxan Monohydrochloride;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride;2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride;2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
- 中文名:
- 盐酸咪唑克生
- 中文别名:
- 盐酸咪唑克生;咪唑克生盐酸盐
- CBNumber:
- CB5236802
- 分子式:
- C11H13ClN2O2
- 分子量:
- 240.69
- MOL File:
- 79944-56-2.mol
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盐酸咪唑克生化学性质
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熔点:
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207-208°
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储存条件:
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Store at RT
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溶解度:
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H2O: 300 mg/mL
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形态:
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Powder
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水溶解性:
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Soluble to 100 mM in water
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稳定性:
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Hygroscopic
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盐酸咪唑克生性质、用途与生产工艺
Idazoxan hydrochloride (RX 781094 hydrochloride) 是一种 α2-肾上腺素受体拮抗剂，也是咪唑啉受体 (IRs) 拮抗剂，可竞争性拮抗唑啉样药物 (IMs) 的中枢性降压作用。Idazoxan hydrochloride 还可改善帕金森氏病，L-DOPA 引起的运动障碍和实验性帕金森病的运动症状。
α
2
-adrenoceptor; Imidazoline receptors (IRs)
Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an
ED
50
of 0.25 mg/kg. Idazoxan (0.3 and 2.5 mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol.
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Animal Model:
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Male CD-COBS rats injected with 1 mg/kg haloperidol
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Dosage:
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0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0 mg/kg
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Administration:
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Subcutaneous injection; for 1 hour
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Result:
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Potently reversed haloperidol-induced catalepsy with an
ED
50
of 0.25 mg/kg.
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盐酸咪唑克生
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14561A | Idazoxan hydrochloride | | 1 mg | 209元 |
| 2024/01/25 | HY-14561A | 盐酸咪唑克生
Idazoxan hydrochloride | 79944-56-2 | 5mg | 500元 |
盐酸咪唑克生
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盐酸咪唑克生国内生产厂家
79944-56-2, 盐酸咪唑克生 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Adrenoceptor
- 有机中间体
- 小分子抑制剂
- 79944-65-2
- 咪唑克生盐酸盐
- 盐酸咪唑克生
- 79944-56-2
- RX781094,inhibit,Adrenergic Receptor,RX-781094,Idazoxan,Inhibitor,Beta Receptor,Idazoxan hydrochloride,Imidazoline Receptor
- Idazoxan hydrochlori
- Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
- RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
- IdazoxanHCl
- 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
- IDAZOXAN HYDROCHLORIDE
- 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
- RX 781094A
- 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
- (+/-)-Idazoxan Monohydrochloride