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IDAZOXAN HYDROCHLORIDE

IDAZOXAN HYDROCHLORIDE structure

CAS No.: 79944-56-2

Chemical Name:: IDAZOXAN HYDROCHLORIDE

Synonyms: RX 781094A;IdazoxanHCl;Idazoxan hydrochlori;IDAZOXAN HYDROCHLORIDE;(+/-)-Idazoxan Monohydrochloride;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride;2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride;2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride

CBNumber:: CB5236802

Molecular Formula:: C11H13ClN2O2

Molecular Weight:: 240.69

MDL Number:: MFCD00069293

MOL File:: 79944-56-2.mol

Last updated:2023-05-18 11:31:11

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IDAZOXAN HYDROCHLORIDE Properties

Melting point	207-208°
storage temp.	Store at RT
solubility	H₂O: 300 mg/mL
form	Powder
Water Solubility	Soluble to 100 mM in water
Stability	Hygroscopic
FDA UNII	15394QZS7A

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	Xn
Risk Statements	22
Safety Statements	7
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3

IDAZOXAN HYDROCHLORIDE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I6138	Idazoxan hydrochloride	79944-56-2	50mg	$115	2024-03-01	Buy
Sigma-Aldrich	I6138	Idazoxan hydrochloride	79944-56-2	100mg	$153	2024-03-01	Buy
Sigma-Aldrich	5.04746	IdazoxanHydrochloride-CAS79944-56-2-Calbiochem	79944-56-2	50mg	$146	2022-05-15	Buy
Tocris	0793	Idazoxan hydrochloride ≥98%	79944-56-2	10	$159	2021-12-16	Buy
Tocris	0793	Idazoxan hydrochloride ≥98%	79944-56-2	50	$647	2021-12-16	Buy

Product number	Packaging	Price	Buy
I6138	50mg	$115	Buy
I6138	100mg	$153	Buy
5.04746	50mg	$146	Buy
0793	10	$159	Buy
0793	50	$647	Buy

IDAZOXAN HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

mp 207-209°C

Uses

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Uses

Antiparkinsonian;Alpha2 agonist

Uses

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

IDAZOXAN HYDROCHLORIDE synthesis

Synthesis of IDAZOXAN HYDROCHLORIDE from 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONITRILE and Ethylenediamine

IDAZOXAN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

1,4-Benzodioxin-2-carboximidic acid, 2,3-dihydro-, ethyl ester, hydrochloride (1:1) 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONITRILE Ethylenediamine Catechol

Preparation Products

IDAZOXAN HYDROCHLORIDE Suppliers

Global( 62)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Syntechem Co.,Ltd		info@syntechem.com	China	12990	57
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10269	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky (shanghai) International Co.,Ltd	60
Syntechem Co.,Ltd	57
Hangzhou Sage Chemical Co., Ltd.	58
AdooQ BioScience, LLC	58

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(+/-)-Idazoxan Monohydrochloride 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride RX 781094A 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride IDAZOXAN HYDROCHLORIDE 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE IdazoxanHCl RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride Idazoxan hydrochlori RX781094,inhibit,Adrenergic Receptor,RX-781094,Idazoxan,Inhibitor,Beta Receptor,Idazoxan hydrochloride,Imidazoline Receptor 79944-56-2 79944-65-2 Adrenoceptor Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals