(-)-沙利度胺
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- CAS号:
- 841-67-8
- 英文名:
- (-)-THALIDOMIDE
- 英文别名:
- NSC 91730;(–)-Thalidomide;(-)-THALIDOMIDE;(S)-(-)-THALIDOMIDE;Thalidomide (S)-Isomer;(S)Thalidomide,(S) Thalidomide;6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid;N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide;(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN;(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
- 中文名:
- (-)-沙利度胺
- 中文别名:
- S-沙利度胺;(-)-沙利度胺;化合物 T12644L;S)-(-)-THALIDOMIDE[干冰运输]
- CBNumber:
- CB5762707
- 分子式:
- C13H10N2O4
- 分子量:
- 258.23
- MOL File:
- 841-67-8.mol
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(-)-沙利度胺化学性质
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熔点:
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269-271°C
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沸点:
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401.48°C (rough estimate)
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密度:
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1.2944 (rough estimate)
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折射率:
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1.5300 (estimate)
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO: soluble
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酸度系数(pKa):
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10.70±0.40(Predicted)
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形态:
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solid
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颜色:
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white
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旋光性 (optical activity):
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[α]23/D 62.6°, c = 2 in DMF(lit.)
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(-)-沙利度胺性质、用途与生产工艺
(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S-对映体。(S)-Thalidomide 具有免疫调节,抗炎,抗血管生成和促凋亡作用。(S)-Thalidomide 通过与 cereblon (CRBN) 结合诱导致畸作用。
(S)-Thalidomide treatment results in a reduction in cell viability in U266 cells with an IC
50
of 362 μM.
(S)-Thalidomide treatment increased apoptosis in a dose-dependent manner in U266 cells.
There are changes in the expression profile of genes involved in angiogenesis and apoptosis, but the changes are most dramatic in the apoptotic genes. In particular, the expression of I-κB kinase is decreased by two-fold, which is associated with a four-fold decrease in NF-κB expression. (S)-Thalidomide increases the Bax:Bcl-2 ratio, also increases I-kB protein levels, and decreases NF-kB activity. A dramatic decrease in Bcl-2 expression with (S)-Thalidomide suggests a possible enhancement of cytotoxic effect if combined with other cytotoxic agents.
Cell Viability Assay
Cell Line:
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U266 MM cells
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Concentration:
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0 µM, 10 µM, 100 µM, 150 µM, 200 µM, 1000 µM
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Incubation Time:
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3 days
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Result:
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A reduction in cell viability was observed in U266 cells.
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Apoptosis Analysis
Cell Line:
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U266 MM cells
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Concentration:
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100 µM, 150 µM, 200 µM, 1000 µM
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Incubation Time:
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3 days
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Result:
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Increased apoptosis in U266 cells.
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Thalidomide does cause limb reduction defects in chick embryos as long as the embryos are directly exposed to the drug. The most useful techniques are implanting Thalidomide-soaked beads into the embryo immediately adjacent to the limb territory or soaking presumptive chick limb territories in Thalidomide and then grafting the explants to a host embryo celom. Thalidomide affects the chick limb grafted to a host embryo in a dose response fashion. Furthermore, (S)-Thalidomide is more teratogenic than (R)-Thalidomide.
(-)-沙利度胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-14658A | (S)-Thalidomide | | 5 mg | 700元 |
2024/04/30 | HY-14658A | (S)-Thalidomide | | 10 mg | 1100元 |
(-)-沙利度胺
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841-67-8, (-)-沙利度胺 相关搜索:
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- Extracellular Matrix
- Cytoskeleton and Extracellular Matrix
- 化合物 T12644L
- S)-(-)-THALIDOMIDE[干冰运输]
- (-)-沙利度胺
- S-沙利度胺
- 841-67-8
- (2r)-2,3-bis[(4,4-difluorotetradecanoyl)oxy]propyl 2-(trimethylammonio)ethyl phosphate
- Ibuprofen Impurity 13 (Ibuprofen EP Impurity M Sodium salt)
- (S)Thalidomide,(S) Thalidomide
- (-)-THALIDOMIDE
- (–)-Thalidomide
- 1H-Isoindole-1,3(2H)-dione, 2-[(3S)-2,6-dioxo-3-piperidinyl]-
- Thalidomide (S)-Isomer
- NSC 91730
- N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide
- 2-[(3S)-2,6-Dioxo-3-piperidyl]-1H-isoindole-1,3(2H)-dione
- (3S)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
- (-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide
- (-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN
- (S)-(-)-THALIDOMIDE
- S(-)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE
- (S)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE
- 6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid
- 6-dioxo-3-piperidinyl)-3(2h)-dion(s)-1h-isoindole-2-(2