洛索立宾
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- CAS号:
- 121288-39-9
- 英文名:
- Loxoribine
- 英文别名:
- RWJ 21757;Loxoribine;7,8-Dihydro-8-oxo-7-allyl-guanosine;7-Allyl-7,8-dihydro-8-oxoguanosine 95%;7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95;7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-;7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-;7-Allyl-7,8-dihydro-8-oxoguanosine
(Loxoribine)
- 中文名:
- 洛索立宾
- 中文别名:
- 洛索立宾;7-烯丙基-8-氧代鸟苷;7-烯丙基-7,8-二氢-8-氧代鸟苷;7-烯丙基-7,8-二氢-8-羰基鸟苷;7-烯丙基-2-氨基-9-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-1H-嘌呤-6,8(7H,9H)-二酮
- CBNumber:
- CB7499469
- 分子式:
- C13H17N5O6
- 分子量:
- 339.3
- MOL File:
- 121288-39-9.mol
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洛索立宾化学性质
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熔点:
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227-230 °C(lit.)
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密度:
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1.92±0.1 g/cm3(Predicted)
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储存条件:
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Desiccate at +4°C
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溶解度:
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Soluble in DMSO (up to 25 mg/ml).
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形态:
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White to off-white solid.
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酸度系数(pKa):
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10.29±0.20(Predicted)
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颜色:
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White
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旋光性 (optical activity):
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[α]21/D 32°, c = 1 in H2O
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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洛索立宾性质、用途与生产工艺
洛索立宾在抗肿瘤反应中充当合成佐剂。
Loxoribine (7-Allyl-8-oxoguanosine) 是一种鸟苷类似物，具有抗病毒和抗肿瘤活性。Loxoribine 是一种口服生物可利用、选择性的 TLR7 激动剂。
Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability.
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7.
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway.
Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo.
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Animal Model:
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8-12 weeks male CBA/J mice
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Dosage:
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2 mg
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Administration:
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Subcutaneous or intravenous injection
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Result:
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activates murine natural killer (NK) cells in vivo.
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洛索立宾
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108472 | 洛索立宾
Loxoribine | 121288-39-9 | 5mg | 495元 |
| 2024/04/30 | HY-108472 | 洛索立宾
Loxoribine | 121288-39-9 | 10mM * 1mLin DMSO | 545元 |
洛索立宾
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121288-39-9, 洛索立宾 相关搜索:
- Specialty Synthesis
- Oligonucleotide Synthesis
- Nucleosides
- Nucleotides
- Heterocycles
- Bases & Related Reagents
- Heterocyclic Compounds
- 7-烯丙基-2-氨基-9-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)-1H-嘌呤-6,8(7H,9H)-二酮
- 7-烯丙基-7,8-二氢-8-氧代鸟苷
- 7-烯丙基-7,8-二氢-8-羰基鸟苷
- 7-烯丙基-8-氧代鸟苷
- 洛索立宾
- 121288-39-9
- RWJ-21757,Loxoribine,natural,Toll-like Receptor (TLR),killer,cells,Influenza Virus,Inhibitor,cells,inhibit,TLR-7,MoDCs,RWJ21757
- 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95 USP/EP/BP
- 7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine
- Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-
- 7-Allyl-7,8-dihydro-8-oxoguanosine
(Loxoribine)
- 7,8-Dihydro-8-oxo-7-allyl-guanosine
- 7-Allyl-7,8-dihydro-8-oxoguanosine 95%
- Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-
- RWJ 21757
- 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
- 7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione
- Loxoribine
- 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95