净特罗
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- CAS号:
- 37000-20-7
- 英文名:
- N-(2-HYDROXY-5-(1-HYDROXY-2-(2-METHYL-1-PHENYLPROPAN-2-YLAMINO)ETHYL)PHENYL)METHANE
- 英文别名:
- MJ 9184;Zinterol;Zinterol hydrochlori;N-{5-[2-(1,1-DiMethyl-2-phenyl-ethylaMino)-1-hydroxy-ethyl]-2-hydroxy-phenyl}-MethaesulfonaMide;Methanesulfonamide, N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-;N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamidehydrochloride
- 中文名:
- 净特罗
- 中文别名:
- 净特罗;化合物 T13399
- CBNumber:
- CB91119179
- 分子式:
- C19H26N2O4S
- 分子量:
- 378.49
- MOL File:
- 37000-20-7.mol
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净特罗化学性质
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沸点:
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574.3±60.0 °C(Predicted)
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密度:
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1.282±0.06 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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Soluble to 5 mM in water and to 100 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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8.57±0.50(Predicted)
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净特罗性质、用途与生产工艺
Zinterol (MJ 9184) 是一种有效的选择性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Zinterol 增强 ICa，EC50 为 2.2 nM。
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
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Animal Model:
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In New Zealand White HF rabbits of either sex
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Dosage:
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1.0 or 2.5 μg/kg
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Administration:
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Intravenous bolus administration; over 5 seconds
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Result:
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2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
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净特罗
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2023/03/20 | HY-14304 | 净特罗
Zinterol | 37000-20-7 | 1mg | 1550元 |
| 2023/03/20 | HY-14304 | 净特罗
Zinterol | 37000-20-7 | 10mM * 1mLin DMSO | 3872元 |
净特罗
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净特罗国内生产厂家
37000-20-7, 净特罗 相关搜索:
- C19H26N2O4S
- 化合物 T13399
- 净特罗
- 37000-20-7
- Zinterol hydrochlori
- Methanesulfonamide, N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-
- MJ 9184
- N-{5-[2-(1,1-DiMethyl-2-phenyl-ethylaMino)-1-hydroxy-ethyl]-2-hydroxy-phenyl}-MethaesulfonaMide
- N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamidehydrochloride
- Zinterol