K-252A
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- CAS号:
- 99533-80-9
- 英文名:
- K-252A
- 英文别名:
- PROTEIN KINASE INHIBITOR;sf2370;K-252A;antibiotick252a;K 252a(SF 2370);antibioticsf2370;K-252A, NOCARDIOPSIS SP;(9-alpha,10-beta,12-alpha)-este;PROTEIN KINASE INHIBITOR K-252A;J61687 Protein Kinase Inhibitor K252A
- 中文名:
- K-252A
- 中文别名:
- 抑制剂试剂;K252A型;化合物 T15636;K-252A蛋白酶抑制剂;(+)-抗生素 K 252A;K252A (PKC抑制剂);K-252A,蛋白质和CAM激酶抑制剂;ANTIBIOTIC K 252A|||ANTIBIOTIC SF 2370|||SF2370;(9S,10R,12R)-9,12-环氧-1H-二吲哚并[1,2,3-fg：3',2',1'-kl]吡咯并[3,4-i][1,6]苯并重氮辛-10-羧酸,2,3,9,10,11,12-六氢-10-羟基-9-甲基-1-氧代甲酯
- CBNumber:
- CB9493885
- 分子式:
- C27H21N3O5
- 分子量:
- 467.47
- MOL File:
- 99533-80-9.mol
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K-252A化学性质
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熔点:
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262-273℃ (decomposition) (methanol )
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沸点:
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685.3±55.0 °C(Predicted)
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密度:
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1.68
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闪点:
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87℃
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储存条件:
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-20°C
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溶解度:
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DMF: 1 mg/mL
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酸度系数(pKa):
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11.95±0.40(Predicted)
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形态:
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Lyophilized solid.
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颜色:
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White or off-white
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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K-252A性质、用途与生产工艺
K-252a 可从土壤真菌Nocardiopsis sp.中分离得到的一种十字孢碱的类似物，是蛋白激酶的抑制剂，对 PKC、PKA、II型钙调素依赖性激酶和磷酸化酶激酶的 IC50 值分别为470 nM、140 nM、270 nM和1.7 nM。K-252a 是一种有效抑制 NGF 受体 gp140trk 的酪氨酸蛋白激酶 (TRK) 活性，IC50 为 3 nM。
K-252a 可从土壤真菌Nocardiopsis sp.中分离得到的一种十字孢碱的类似物，是蛋白激酶的抑制剂，对 PKC、PKA、II型钙调素依赖性激酶和磷酸化酶激酶的 IC50 值分别为470 nM、140 nM、270 nM和1.7 nM。K-252a 是一种有效抑制 NGF 受体 gp140trk 的酪氨酸蛋白激酶 (TRK) 活性，IC50 为 3 nM。
IC50: 470 nM (PKC), 140 nM (PKA), 270 nM (Ca
2+
/calmodulin-dependent kinase type II), 1.7 nM (phosphorylase kinase).
K-252a (3-100 nM, 8d) inhibits NGF-promoted neurite outgrowth.
Western Blot Analysis.
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Cell Line:
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LINC00641-overexpressed cell line.
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Concentration:
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1.7 nM (NGF (50 ng/mL)).
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Incubation Time:
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6 h.
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Result:
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Decreased p-Akt and p-TrkB levels.
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Cell Viability Assay.
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Cell Line:
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PC12 subclone h cells.
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Concentration:
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3 to 100 nM.
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Incubation Time:
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8 d.
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Result:
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Inhibited NGF-promoted neurite outgrowth.
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K252a (20 mg/kg/day) inhibiting TrkB pathway dampens the neuroprotective effects induced by TH.
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Animal Model:
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Mice.
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Dosage:
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20 mg/kg/day.
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Administration:
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Intraperitoneally, daily, for consecutive 5 days.
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Result:
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Dampened the neuroprotective effects induced by TH.
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K-252A
上下游产品信息
上游原料
下游产品
K-252A
生产厂家
全球有 145家供应商
K-252A国内生产厂家
99533-80-9, K-252A 相关搜索:
- Protein Kinase Inhibitors and Related ProductsKinase/Phosphatase Biology
- Antibiotics G-MCell Signaling and Neuroscience
- Protein Kinase
- Serine/Threonine Kinase Inhibitors
- Serine/Threonine Kinase Biology
- Protein Kinases and Phosphatases
- Kinase/Phosphatase Biology
- Antibiotics A to
- Antibiotics
- Protein Kinase InhibitorsEnzymes, Inhibitors, and Substrates
- antibiotic
- 生化试剂
- 化学试剂
- 原料药
- 化工原料
- 抗生素
- Antibiotics G-M
- Antibiotics A to Z
- Antibiotics
- BioChemical
- ANTIBIOTIC K 252A|||ANTIBIOTIC SF 2370|||SF2370
- K-252A,蛋白质和CAM激酶抑制剂
- K252A (PKC抑制剂)
- 抑制剂试剂
- 化合物 T15636
- K252A型
- (9S,10R,12R)-9,12-环氧-1H-二吲哚并[1,2,3-fg：3',2',1'-kl]吡咯并[3,4-i][1,6]苯并重氮辛-10-羧酸,2,3,9,10,11,12-六氢-10-羟基-9-甲基-1-氧代甲酯
- K-252A蛋白酶抑制剂
- (+)-抗生素 K 252A
- 99533-80-9
- (5S,6R,8R)-Methyl 6-hydroxy-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylate
- PROTEIN KINASE INHIBITOR
- J61687 Protein Kinase Inhibitor K252A
- 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-
- K-252A
- PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.)
- (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1.2.3-fg.3'.2'.1'-kl]pyrrolo[3.4-
- PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.
- PROTEIN KINASE INHIBITOR K-252A
- (9S,10R,12R)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER
- K-252A, NOCARDIOPSIS SP
- sf2370
- antibioticsf2370
- antibiotick252a
- 9,1-epoxy-1h-diindolo(1,2,3-fg:3’,2’,1’-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1
- 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0-carboxylicacimethyl
- K 252a(SF 2370)
- (9α,10β,12α)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-Methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid Methyl ester
- 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-
- 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-
- [9S,(+)]-2,3,9,10,11,12-Hexahydro-10α-hydroxy-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
- (9-alpha,10-beta,12-alpha)-este