LAPAQUISTAT

189060-13-7

CAS-Nr.: 189060-13-7

Englisch Name:: LAPAQUISTAT

Synonyma:: TAK-475;CS-1400;LAPAQUISTAT;Lapaquistat Acetate;Lapaquistat Acetate (TAK-475);Lapaquistat and Lapaquistat Acetate;1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid;4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-;2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid

CBNumber:: CB01509119

Summenformel:: C33H41ClN2O9

Molgewicht:: 645.14

MOL-Datei:: 189060-13-7.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 28

LAPAQUISTAT Eigenschaften

Schmelzpunkt:: 194-196℃

Siedepunkt:: 826.4±65.0 °C(Predicted)

Dichte: 1.246±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 4.66±0.10(Predicted)

Farbe: White

Sicherheit

LAPAQUISTAT Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.

LAPAQUISTAT Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LAPAQUISTAT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 28)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	sales@zhiwe.net	China	579	61
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Wulechem Co., Ltd.	13761914825	wulesian@wulechem.com	China	304	58
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Nanjing NingFan Pharm-Tech CO. LTD.	17368696818		China	1986	58

LAPAQUISTAT
Lapaquistat and Lapaquistat Acetate
Lapaquistat Acetate
2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid
TAK-475
1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
CS-1400
Lapaquistat Acetate (TAK-475)
4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
189060-13-7
C33H41ClN2O9
Amines
Chiral Reagents
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals