Toosendanin

Toosendanin Struktur
58812-37-6
CAS-Nr.
58812-37-6
Englisch Name:
Toosendanin
Synonyma:
Toosendani;Chuanliansu;TOOSENDANIN;Toosendaninr;Toosendan extract;Toosendan Fructus。;28-Deacetylsendanin;Toosendanin USP/EP/BP;12-AcetoxyaMoorastatin;Toosendanin 58812-37-6
CBNumber:
CB0187835
Summenformel:
C30H38O11
Molgewicht:
574.62
MOL-Datei:
58812-37-6.mol

Toosendanin Eigenschaften

Schmelzpunkt:
170-175°C
Siedepunkt:
555.97°C (rough estimate)
Dichte
1.2084 (rough estimate)
Brechungsindex
1.5970 (estimate)
storage temp. 
Refrigerator
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
pka
12.15±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Pale Beige
CAS Datenbank
58812-37-6
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 24/25
HS Code  29389090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P321 Besondere Behandlung
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Toosendanin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fructus Meliae Toosendan (chuan lian zi), the fruit of Melia toosendan Sieb. Et Zucc, is mainly produced in Sichuan, Hubei, Henan, and Hunan province in China .
Toosendanin is a tetracyclic triterpene compound extracted from fructus toosendan. It is an ascaridole agent and showed anti-botulinum, antibacterial, anticancer, and anti-inflammatory effects. It is also a neuromuscular blocking agent.

Physikalische Eigenschaften

Appearance: white acicular crystal, colorless, bitter, and odorless. Solubility: soluble in ethanol, methanol, ethyl acetate, acetone, pyridine, etc., and slightly soluble in hot water, chloroform, benzene, and ether and insoluble in petroleum ether.

History

Toosendanin is the main chemical composition of the fructus toosendan. Researches on this compound could date back to 1953. Toosendanin has been named in 1955, while its structure was identified 20 years later by mass spectrometry. Toosendanin is a triterpenoid derivative containing a β-substituted furan ring . A new synthetic strategy is put forth allowing access to a 4-acetoxy CD fragment analogue of toosendanin, which was achieved from mesityl oxide and acetylacetone in 14 steps in 2009 .
The anti-parasite of toosendanin was reported in 1971. In 1980, it was identified as a selective neuromuscular blocking agent that acts on neuromuscular junction . The anti-botulinum effect of toosendanin was discovered in 1982 . In recent years, it is also observed that toosendanin can induce differentiation and apoptosis . Toosendanin could inhibit the growth of feeding larvae and insects. It has been used as pollution-free, no residue of botanical insecticides for the production of fruits and vegetables in China .

Verwenden

Toosendanin is a triterpenoid derivative, acts as a novel agonist of L-type Ca2+ channels in neonatal rat ventricular cells.

Indications

Insecticide

Pharmakologie

By interfering with neurotransmitter release and causing an initial facilitated diffusion toosendanin eventually blocks synaptic transmission at both the neuromuscular junction and central synapses.
Toosendanin is sharing many similar actions with botulinum neurotoxin on blocking neuromuscular transmission, but it has very low biological activity compared with botulinum neurotoxin. Studies suggest that the anti-botulinum effect is achieved by preventing botulinum neurotoxin from approaching its enzymatic substrate, SNARE protein.
Toosendanin can induce differentiation and apoptosis in several cell lines and suppress proliferation of various human cancer cells. It inhibits K+ channel and facilitates L-type Ca2+ channel, which is associated with parts of its biological activities .
In a word, activities of toosendanin include selective neuromuscular blocking, effectively antagonizing botulism, inducing cell differentiation and apoptosis and inhibiting proliferation of various human cancer cells, inhibiting feeding and development in insects, and modifying K+ and Ca2+ channel activity.

Clinical Use

Fructus Meliae Toosendan is a traditional Chinese medicine which is still used in internal medicine.

Toosendanin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Toosendanin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 278)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3424 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202
sale02@cqherb.com CHINA 376 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58

58812-37-6()Verwandte Suche:


  • TOOSENDANIN
  • 24-Norchola-20,22-diene-4-carboxaldehyde,3,12-bis(acetyloxy)-14,15:21,23-diepoxy-1,7,19-trihydroxy-4,8-dimethyl-11-oxo-,cyclic4,19-hemiacetal, [C(R),1α,3α,4β, 5α,7α,12α,13α,14β,15β,17α]-
  • 28-Deacetylsendanin
  • 12-AcetoxyaMoorastatin
  • Toosendan Fructus。
  • Toosendanin 58812-37-6
  • Toosendanin, 98%, from Melia toosendan Sieb. et Zucc.
  • Toosendanin USP/EP/BP
  • Toosendaninr
  • Toosendan extract
  • Chuanliansu
  • Toosendani
  • TOOSENDANIN Toosendanin Chuanliansu Chuanliansu 28-Deacetylsendanin Toosendanin 58812-37-6 12-AcetoxyaMoorastatin
  • Toosendanin, from Melia toosendan Sieb. et Zucc
  • 58812-37-6
  • C30H38O11
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Limonoids (Citrus, Bitter Compounds)
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