NU1025
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- CAS-Nr.
- 90417-38-2
- Englisch Name:
- NU1025
- Synonyma:
- NU1025;NSC 696807;NU 1025;NU 1025;NU1025 USP/EP/BP;NU1025
(NSC 696807);PARP Inhibitor VI, NU1025;8-Hydroxy-2-methylquinazolin-4(3H);8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
- CBNumber:
- CB0214872
- Summenformel:
- C9H8N2O2
- Molgewicht:
- 176.17
- MOL-Datei:
- 90417-38-2.mol
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NU1025 Eigenschaften
- Schmelzpunkt:
- 253-258°C
- Siedepunkt:
- 345.4±44.0 °C(Predicted)
- Dichte
- 1.42
- storage temp.
- −20°C
- Löslichkeit
- DMSO: 35 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- 8.68±0.20(Predicted)
- Farbe
- off-white
- CAS Datenbank
- 90417-38-2
NU1025 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Beschreibung
NU 1025 is an inhibitor of poly(ADP-
ribose) polymerases (PARP) (IC
50 = 400 nM). It enhances the cytotoxicity of γ-
irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.
Chemische Eigenschaften
Off-White to Pale Yellow Solid
Definition
ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Biologische Aktivität
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.
NU1025 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NU1025 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 121)Lieferanten
90417-38-2()Verwandte Suche:
- NU1025
- 8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
- 8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE
- 8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE
- 8-Hydroxy-2-methylquinazoline-4-one ,97%
- 8-hydroxy-2-methyl-1H-quinazolin-4-one
- NSC 696807
- 4(3H)-Quinazolinone, 8-hydroxy-2-Methyl-
- 8-hydroxy-2-methylquinazolin-4(1H)-one
- 8-Hydroxy-2-methylquinazolin-4(3H)
- NU1025
(NSC 696807)
- PARP Inhibitor VI, NU1025
- PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem
- NU 1025;NU 1025
- NU1025 USP/EP/BP
- 90417-38-2
- Kinase/Phosphatase Biology
- Serine/Threonine Kinase Inhibitors
- Cyclin-Dependent Kinase (CDK)
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- All Inhibitors
- Inhibitors
- Aromatics
