Deferiprone
|
|
|
- CAS-Nr.
- 30652-11-0
- Englisch Name:
- Deferiprone
- Synonyma:
- L1;CP20;DMHP;Kelfer;DEFERIPRON;DEFERIDONE;eferiprone;DEFERIPRONE;Deferiprone CRS;deferiprone(DFP)
- CBNumber:
- CB0308124
- Summenformel:
- C7H9NO2
- Molgewicht:
- 139.15
- MOL-Datei:
- 30652-11-0.mol
|
Deferiprone Eigenschaften
- Schmelzpunkt:
- 272-275 °C (lit.)
- Siedepunkt:
- 255.1°C (rough estimate)
- Dichte
- 1.1997 (rough estimate)
- Brechungsindex
- 1.4800 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Soluble in Water (up to 5 mg/ml with warming).
- Aggregatzustand
- Crystalline Powder or Needles
- pka
- pKa1 3.3, pKa2 9.7(at 25℃)
- Farbe
- White to off-white
- Wasserlöslichkeit
- Soluble in hot water
- Merck
- 14,2859
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
- InChI
- InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
- InChIKey
- TZXKOCQBRNJULO-UHFFFAOYSA-N
- SMILES
- C1(C)N(C)C=CC(=O)C=1O
- CAS Datenbank
- 30652-11-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
|
Deferiprone Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Deferiprone is a lipophilic iron chelator that binds to iron at a molar ratio of 3:1 (ligand: iron). Its active form is available orally, making it the only oral iron chelator. Deferiprone is a member of the 4-pyridone family and is a pyridine 4-4 (1H) -one, with a methyl substitution at positions 1 and 2 and a hydroxyl substitution at position 3. By binding to iron, Deferiprone can remove excess iron from the body and prevent serum iron overload in patients with transfusion-dependent thalassemia. It has chelation and protective effects and is primarily used to treat thalassaemia.
Chemische Eigenschaften
White Needles
Verwenden
A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro
Definition
ChEBI: Deferiprone is a member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. It has a role as an iron chelator and a protective agent.
Allgemeine Beschreibung
3-Hydroxy-1,2-dimethyl-4(1
H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative.
It reacts with uranyl salts [UO
2(NO
3)
2] in aqueous acidic solution to afford mono nuclear complexes ([UO
2(dpp)(Hdpp)
2(H
2O)]ClO
4). X-ray studies have been conducted to examine the structure and geometry of these complexes.
Deferiprone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Deferiprone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 325)Lieferanten
30652-11-0()Verwandte Suche:
- L1
- DMHP
- DEFERIDONE
- DEFERIPRON
- DEFERIPRONE
- CP20
- 3-HYDROXY-1,2-DIMETHYL-4(1H)PYRIDINONE
- 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE
- TIMTEC-BB SBB006753
- 1,2-DIMETHYL-3-HYDROXY-4-PYRIDONE
- 1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE
- 1,2-DIMETHYL-3-HYDROXYPYRIDIN-4-ONE
- 1,2-DIMETHYL-3-HYDROXYPYRIDINE-4-ONE
- 1,2-dimethyl-3-hydroxy-4(1h)-pyridinon
- 1,2-dimethyl-3-hydroxy-4(1h)-pyridinone
- 3-hydroxy-1,2-dimethyl-4(1h)-pyridon
- cp20(chelatingagent)
- 3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE, 9 8%
- deferiprone(DFP)
- 1,2-Dimethyl-3-hydroxy-4-pyridone, 99+%
- Kelfer
- 1,2-DiMethyl-3-hydroxy-4-pyridone, 99+% 10GR
- 4(1H)-Pyridinone,3-hydroxy-1,2-diMethyl-
- 1,2-Dimethyl-3-hydroxy-1,4-dihydropyridine-4-one
- 3-Hydroxy-1,2-diMethylpyridin-4(1H)-one
- DEFERIPRONE PHARMACEUTICAL RAW MATERIALS
- 3-Hydroxy-1,2-dimethyl-1,4-dihydropyridin-4-one
- 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, 98.5%
- Deferiprone CRS
- 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone>
- eferiprone
- Deferiprone ISO 9001：2015 REACH
- DeferiproneQ: What is
Deferiprone Q: What is the CAS Number of
Deferiprone Q: What is the storage condition of
Deferiprone Q: What are the applications of
Deferiprone
- 3-hydroxy-1,2-dimethylpyridin-4-one
- Debrisoquine Hemisulfate-13C
- 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone, ≥ 98.0%
- 30652-11-0
- C7H9NO2
- ALCOHOL
- Building Blocks
- Heterocyclic Building Blocks
- Piperidones
- Heterocycles
- API intermediates
- Chelating Agents, Ligands
- Chelating Agents & Ligands
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Building Blocks
- Heterocyclic Building Blocks
- Piperidones
