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ZSTK474

ZSTK474 Struktur
475110-96-4
CAS-Nr.
475110-96-4
Englisch Name:
ZSTK474
Synonyma:
CS-438;ZSTK 474;ZSTK474 BASE;ZSTK474/ZSTK-474;ZSTK474 USP/EP/BP;2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine;2-(DifluoroMethyl)-1-[4,6-di(4-Morpholinyl)-1,3,5-triazin-2-yl]-1H-benziMidaz;2-(difluoromethyl)-1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-1H-benzo[d]imidazole;ZSTK 474 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine;2-(DifluoroMethyl)-1-[4,6-di(4-Morpholinyl)-1,3,5-triazin-2-yl]-1H-benziMidazole
CBNumber:
CB0505419
Summenformel:
C19H21F2N7O2
Molgewicht:
417.41
MOL-Datei:
475110-96-4.mol
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ZSTK474 Eigenschaften

Schmelzpunkt:
217-219 °C(Solv: ethanol (64-17-5))
Siedepunkt:
640.3±65.0 °C(Predicted)
Dichte
1.57
storage temp. 
-20°C
Löslichkeit
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming).
Aggregatzustand
White powder.
pka
5.21±0.10(Predicted)
Farbe
White or off-white
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Sicherheit

HS Code  29349990

ZSTK474 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 μM. ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice. The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.

Definition

ChEBI: A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.

ZSTK474 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ZSTK474 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 156)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32715 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49391 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 27644 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739
 info@dycnchem.com CHINA 52861 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58

475110-96-4()Verwandte Suche:

Benzyl-(S)-2-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]pyrrolidin-1-carboxylat 4-Nitrophenyl-3-phenyl-N-[(phenylmethoxy)carbonyl]-L-alaninat Benzyl-(S)-[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxo-1-(phenylmethyl)ethyl]carbamat
  • 2-(DifluoroMethyl)-1-[4,6-di(4-Morpholinyl)-1,3,5-triazin-2-yl]-1H-benziMidazole
  • 1H-BenziMidazole, 2-(difluoroMethyl)-1-(4,6-di-4-Morpholinyl-1,3,5-triazin-2-yl)-
  • ZSTK474 BASE
  • ZSTK474/ZSTK-474
  • 2-(difluoromethyl)-1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-1H-benzo[d]imidazole
  • 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine ZSTK-474
  • ZSTK 474 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
  • ZSTK 474
  • 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
  • 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
  • CS-438
  • 2-(DifluoroMethyl)-1-[4,6-di(4-Morpholinyl)-1,3,5-triazin-2-yl]-1H-benziMidaz
  • 4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
  • ZSTK474 USP/EP/BP
  • 3-Oxazolidinecarboxylicacid,2,2-dimethyl-4-(2-oxoethyl)-,1,1-dimethylethylester,(8S)-
  • 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine
  • 475110-96-4
  • C19H21F2N7O2
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
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