PD407824

622864-54-4

CAS-Nr.: 622864-54-4

Englisch Name:: PD407824

Synonyma:: PD407824;PD 0407824;PD-407824, ≥98% (HPLC);9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-

CBNumber:: CB11075013

Summenformel:: C20H12N2O3

Molgewicht:: 328.32

MOL-Datei:: 622864-54-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 39

PD407824 Eigenschaften

Dichte: 1.507±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: >10mg/mL

Aggregatzustand: powder

pka: 9.02±0.20(Predicted)

Farbe: yellow to orange

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26
WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizität (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung	src="/GHS07.jpg" width="20" height="20" />

Sicherheit

P261	Einatmen von Staub vermeiden.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

PD407824 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC₅₀s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC₅₀ = 3.4 μM), Cdk4 (IC₅₀ = 3.75 μM), as well as c-Src and the PDGF and FGF receptors (IC₅₀s = >50 μM for all), and other Cdks (IC₅₀s = >50 μM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 μM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.

Verwenden

PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments.

Biologische Aktivität

Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC 50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC 50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μ M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.

PD407824 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PD407824 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 39)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Jizhi Biochemical Technology Co. Ltd.	400-400-400-9004166 18616739031	3007523370@qq.com	China	52712	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55936	58
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58

PD 0407824
PD407824
9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-
PD-407824, ≥98% (HPLC)
622864-54-4
C20H12N2O3
Amines
Aromatics
Inhibitors
Intermediates & Fine Chemicals
Pfizer compounds
Pharmaceuticals