Docetaxel
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- CAS-Nr.
- 114977-28-5
- Englisch Name:
- Docetaxel
- Synonyma:
- TAXOTERE;rp56976;BIND-014;Doxetaxel;Decetaxel;Anhydrous Docetaxel;Docetere;Docetaxel;Docetaxet;NSC_628503
- CBNumber:
- CB1163212
- Summenformel:
- C43H53NO14
- Molgewicht:
- 807.88
- MOL-Datei:
- 114977-28-5.mol
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Docetaxel Eigenschaften
- Schmelzpunkt:
- 186-192 °C (dec.)
- alpha
- -36 º (c=0.74,EtOH)
- Siedepunkt:
- 900.5±65.0 °C(Predicted)
- Dichte
- 1.38
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride.
- pka
- 11.20±0.46(Predicted)
- Farbe
- White
- Wasserlöslichkeit
- Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
- Merck
- 14,3397
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- BEDLLNJKXXVTSX-LWWLJZAUSA-N
- LogP
- 2.456 (est)
- CAS Datenbank
- 114977-28-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H341 |
Kann vermutlich genetische Defekte verursachen. |
Keimzellmutagenität |
Kategorie 2 |
Warnung |
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P201,P202, P281, P308+P313, P405,P501 |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
| H372 |
Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P314, P501 |
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| Sicherheit |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Docetaxel Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Docetaxel, a semi-synthetic product from the taxoid family, was launched in
1995 first in South Africa and subsequently in several other markets for the treatment of
ovarian, breast and non-small cell lung cancers. Like the naturally occurring antitumor
agent paclitaxel, the first marketed taxoid, docetaxel promotes both the rate and extent
of tubulin assembly into stable microtubules and inhibits their depolymerization. It acts
as a mitotic spindle poison and induces a mitotic block in proliferating cells. This
mechanism of action for taxoids is unique from other classes of anticancer agents.
Docetaxel was reported to be twice as potent as paclitaxel in several in vitro protocols
and also exhibit higher cytotoxicity. Clinical trials are on going for docetaxel for other
types of tumors including pancreatic, gastric, head and neck cancers and soft tissue
sarcomas.
Chemische Eigenschaften
Off-white Cryst
Verwenden
Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM). It has proven more effective than taxol in preventing the proliferation of cancer cells. Docetaxel has applications in breast cancer and hormone-refractory prostate cancer. This product is intended for research applications.
Definition
ChEBI: A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.
Hazard
A poison. Human systemic effects.
Docetaxel Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Docetaxel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 889)Lieferanten
114977-28-5()Verwandte Suche:
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Docetaxel N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol
- Taxotere anhydrous
- n-debenzoyl-n-tert-butoxycarbonyl-10-deacetyl taxol
- )benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph
- Benzenepropanoic acid, b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trih
ydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (aR,bS)-
- DOCETAXEL ANHYDROUS 99.5%
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- docetaxcel，DTX
- N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl
- Docetaxel(other anti-cancers)
- Docetaxel
- DOCETAXEL OR TAXOTERE
- NSC_628503
- N-DEBENZOYL-N-BOC-10-DEACETYL TAXOL
- Taxotere(R)
- Benzenepropanoic acid, beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (alphaR,betaS)-
- Docetaxel9.5%
- Docetaxel (Trihydrate/Anhydrous)
- DOCETAXEL(P)
- -,12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydr
- benzenepropanoicacid,beta-(((1,1-dimethylethoxy)carbonyl)amino)-alpha-hydroxy
- beta-s*),11-alpha,12-alpha,12a-alpha,12b-alpha))-a-r
- o-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1h-cyclodeca(3,4
- DOCETAXEL (TAXOTERE)
- DocetaxelAnhydrous/Trihydrate
- DocetaxelAnhydrousin-HouseStandard
- Docetaxel99.5%
- [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylesterbenzenepropanoicacid
- Docetaxel >99%
- Docetaxel Anhydrous(Taxotere)
- (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]aMino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetraMethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
- [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyc
- Benzenepropanoic acid, beta-[[(1,1-diMethylethoxy)carbonyl]aMino]-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano
- Docetere
- Docetaxel￡DOC
- Decetaxel anhydrous
- Docetaxet
- docetaxel api
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramet
- Docetaxel RS
- Anhydrous Docetaxel CRS
- (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-ylbenzoate
- TAXOTERE,DOCETAXEL
- Docetaxel USP/EP/BP
- Docetaxel1
- Taxotere Docetaxel Powder CAS 114977-28-5
- Docetaxel (RP 56976)
- Docetaxel, 97%+
- DocetaxelQ: What is
Docetaxel Q: What is the CAS Number of
Docetaxel Q: What is the storage condition of
Docetaxel Q: What are the applications of
Docetaxel
- TAXOTERE
- BIND-014
- rp56976
- Anhydrous Docetaxel
- Doxetaxel
- 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-61-THIOSEMICARBAZIDE
- Methanol,6-chloro-,benzoate
- Phenol,9-(bromomethyl)-,acetate
