3-(Indol-3-yl)propionsure
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- CAS-Nr.
- 830-96-6
- Bezeichnung:
- 3-(Indol-3-yl)propionsure
- Englisch Name:
- 3-Indolepropionic acid
- Synonyma:
- PROPAN-2-OL;INDOLE-3-PROPIONIC ACID;3-(1H-INDOL-3-YL)PROPANOIC ACID;ISOPROPANE;ISOPROPYL ALCOHO;ISOPROPANOL ALCOHOL;INDOLEPROPIONIC ACID;2-PPROPANOL;FEMA 2929;ISOPROPANO
- CBNumber:
- CB1183728
- Summenformel:
- C11H11NO2
- Molgewicht:
- 189.21
- MOL-Datei:
- 830-96-6.mol
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3-(Indol-3-yl)propionsure Eigenschaften
- Schmelzpunkt:
- ~133 °C
- Siedepunkt:
- 82 °C(lit.)
- Dichte
- 0.960 g/mL at 20 °C
- Dampfdichte
- 2.1 (vs air)
- Dampfdruck
- 33 mm Hg ( 20 °C)
- Brechungsindex
- n20/D 1.377(lit.)
- Flammpunkt:
- 53 °F
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- ethanol: soluble50mg/mL, clear, yellow to orange
- pka
- 4.77±0.10(Predicted)
- Aggregatzustand
- crystalline
- Farbe
- light yellow
- Wasserlöslichkeit
- slightly soluble
- BRN
- 147733
- CAS Datenbank
- 830-96-6(CAS DataBase Reference)
- NIST chemische Informationen
- Indole-3-propionic acid(830-96-6)
- EPA chemische Informationen
- 1H-Indole-3-propanoic acid (830-96-6)
3-(Indol-3-yl)propionsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36:Reizt die Augen.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S7:Behälter dicht geschlossen halten.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC
50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.
Chemische Eigenschaften
pale yellow to yellow crystalline powder
Verwenden
3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.
Definition
ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.
Allgemeine Beschreibung
3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.
läuterung methode
Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]
3-(Indol-3-yl)propionsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-(Indol-3-yl)propionsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 681)Lieferanten
830-96-6(3-(Indol-3-yl)propionsure)Verwandte Suche:
- 2-HYDROXYPROPANE
- 3-(1H-INDOL-3-YL)-PROPIONIC ACID
- 3-(3-INDOLYL)PROPANOIC ACID
- 3-(3-INDOLYL)-PROPIONIC ACID
- AKOS BBS-00006584
- AKOS BBS-00004245
- 3-INDOLEPROPIONIC ACID
- DIMETHYLCARBINOL
- INDOLE 3-PROPANOIC ACID
- ISO-PROPYL RUBBING ALCOHOL
- LABOTEST-BB LT00044477
- RUBBING ALCOHOL
- TIMTEC-BB SBB000276
- SEC-PROPYL ALCOHOL
- beta-indolepropionicacid
- Indolyl-3-propionicacid
- Ipa (auxin)
- ISO-PRORYL ALCOHOL(IPA)
- ALCOHOL ISOPROPYL USP ANYHDROUS
- ISO PRORYL ALCOHOL
- ISO PROPYLE ALCOHOL
- Ethyl #niso-nicotinate
- INDOLE-3-PROPIONIC ACID PLANT CELL*CULTU RE TESTED
- 3-(3-INDOLYL)-PROPIONIC ACID PESTANAL, 2
- Indole-3-PropionicAcid(Ipa)98%Min
- Indole-3-PropionicAcidForBiochemistry
- INDOL33YLPROPIONICACID
- 3-(Indol-3-yl)propanoic acid
- IPA (Isopropyl Alcohol), 70% v/v
- ISOPROPYL LACOHOL
- ISO PROPYL ALCOHOL ( IPA )
- 3-(indol-3-yl)propionic acid
- 1h-indole-3-propanoicacid
- 1H-Indole-3-propionic acid
- 1h-indole-3-propionicacid
- 3-(2-Carboxyethyl)-1H-indole
- 3-(3-Indole)propionic acid
- 3-(3-Indoly)propionicacid
- 3-Indolylpropionicacid
- IPA, 3-Indole propionic acid
- 3-Indolepropionic acid, 99% 10GR
- 3-(1H-Indazol-1-yl)propanoic acid
- 3-Indole propionic acid (IPA)
- Indole-3-propionic acid,3-(3-Indolyl)propanoic acid, 3-(3-Indolyl)propionic acid, IPA
- 3-Indolepropionic ac
- beta-(3-Indolyl)propionic acid
- beta-Indole-3-propionic acid
- beta-Indolepropionic acid
- 3-(3-Indolyl)propanoic acid, Indole-3-propionic acid, IPA
- 3-(3-Indolyl)propanoic acid, 3-(3-Indolyl)propionic acid, IPA
- 2-Propanol : Water 31:69 with 0.1% buffer, 2-Propanol solution
- N-Term LC Solvent System B
- 3-Indolepropionic acid ,99%
- 3-(3-IP)
- NSC 3252
- NSC 47831
- 2-Propanol : Water 31:69 with 0.1% buffer
- 3-Indolepropionic acid Vetec(TM) reagent grade, 99%
