Pilocarpinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R26/28:Sehr giftig beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S25:Berührung mit den Augen vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Crystalline Solid
Verwenden
(+)-Pilocarpine hydrochloride is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively. Systemic administration of (+)-Pilocarpine hydrochloride is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.
Allgemeine Beschreibung
Pilocarpine monohydrochlorideis the hydrochloride of an alkaloid obtainedfrom the dried leaflets of Pilocarpus jaborandi or P. microphyllus,in which it occurs to the extent of about 0.5% togetherwith other alkaloids.
Biologische Aktivität
Muscarinic agonist.
Clinical Use
Pilocarpine, the salt of an alkaloid obtained from Pilocarpus jaborandi, is an example of a muscarinic agonist that does not adhere to the
traditional SAR. In 1876, Langley reported that extracts containing the alkaloid stimulated the end organs of parasympathetic neurons. The
structure of pilocarpine was reported in 1901.
Pilocarpine is marketed as tablets (Salogen), an ophthalmic solution, and gel. It penetrates the eye well and is the miotic of choice for
open-angle glaucoma and to terminate acute angle closure attacks. It also is used for the treatment of xerostomia (dryness of the mouth) caused
by radiation therapy of the head and neck, Sjogren's syndrome, or as a side effect of some psychotropic drugs.
Sicherheitsprofil
Poison by ingestion,
intraperitoneal, and intravenous routes.
Experimental teratogenic and reproductive
effects. Human systemic effects: cardiac
changes. When heated to decomposition it
emits very toxic fumes of HCl and NOx.
See also PILOCARPINE.
Pilocarpinhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
