Dabigatran Acyl-β-D-Glucuronide

Dabigatran Acyl-β-D-Glucuronide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

Verwenden

Dabigatran Acyl-β-D-Glucuronide Trifluoroacetic Acid Salt is a major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).

Dabigatran Acyl-β-D-Glucuronide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dabigatran Acyl-β-D-Glucuronide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Guangzhou Tosun Pharmaceutical Limited	+8618922120635	sales@toref-standards.com	China	1000	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17993	56
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Artis Biotech Co. Ltd.	19138486554 18582380095	sales@artisbio.com	China	2862	58
Clearsynth Canada Inc.	+1.415.685.4395	enquiry@clearsynth.com	Canada	912	58

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• Dabigatran Acyl-β-D-Glucuronide
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