[2R-(2R*,3S*,6S*,7R*,8R*)]-8-Butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylisovalerat

Antimycin A3 Struktur
522-70-3
CAS-Nr.
522-70-3
Bezeichnung:
[2R-(2R*,3S*,6S*,7R*,8R*)]-8-Butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylisovalerat
Englisch Name:
Antimycin A3
Synonyma:
Nsc58239;Blastmycin;Aids012099;A 80021F34;Aids-012099;antimycina3;BlastMycin, NSC 58239;Antimycin A3 DISCONTINUED, offer A697508;ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer;isovalericacid,n-esterwithn-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-d
CBNumber:
CB2259813
Summenformel:
C26H36N2O9
Molgewicht:
520.57
MOL-Datei:
522-70-3.mol

[2R-(2R*,3S*,6S*,7R*,8R*)]-8-Butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylisovalerat Eigenschaften

Schmelzpunkt:
170.5-171.5° (Liu); 174-174.5° (Kinoshita)
alpha 
D26 +64.3° (chloroform) (Liu); D24 +80° (Kinoshita)
Siedepunkt:
603.87°C (rough estimate)
Dichte
1.2829 (rough estimate)
Brechungsindex
1.5300 (estimate)
storage temp. 
−20°C
Löslichkeit
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
Aggregatzustand
A solid
CAS Datenbank
522-70-3

Sicherheit

Kennzeichnung gefährlicher T
R-Sätze: 23/24/25
S-Sätze: 36/37/39-45
RIDADR  3172
RTECS-Nr. NY1502900
HazardClass  6.1(a)
PackingGroup  II
Toxizität LD50 in mice (mg/kg): 1.8 i.p.; 1.6 s.c. (Watanabe)

[2R-(2R*,3S*,6S*,7R*,8R*)]-8-Butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylisovalerat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.

Verwenden

Antimycin A3 is a homologue of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A4. Antimycin A3 is a more polar analogue of A1 and A2. Like all antimycins, antimycin A3 is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active. Lack of availability of the individual antimycin components has hindered greater understanding of the common and unique molecular targets of the components of the antimycin complex.

mögliche Exposition

Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

[2R-(2R*,3S*,6S*,7R*,8R*)]-8-Butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-ylisovalerat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


  • antimycina3
  • ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer
  • isovalericacid,n-esterwithn-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-d
  • [2R-(2R*,3S*,6S*,7R*,8R*)]-8-butyl-3-(3-formamidosalicylamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
  • Blastmycin
  • 3-Methyl-butyric acid (2R,3S,6S,7R,8R)-8-butyl-3-{[1-(3-formylamino-2- hydroxy-phenyl)-methanoyl]-amino}-2,6-dimethyl-4,9-dioxo-[1,5]dioxonan -7-yl ester
  • A 80021F34
  • Aids012099
  • Aids-012099
  • Nsc58239
  • BlastMycin, NSC 58239
  • Antimycin A3 DISCONTINUED, offer A697508
  • 522-70-3
  • C26H36N2O9
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