Nitrendipin
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- CAS-Nr.
- 39562-70-4
- Bezeichnung:
- Nitrendipin
- Englisch Name:
- Nitrendipine
- Synonyma:
- Nitrendipin;3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Deiten;nidrel;Nitrepin;baye5009;baypress;bayotensin;Bylotensin;NITRENDIPINE
- CBNumber:
- CB2395104
- Summenformel:
- C18H20N2O6
- Molgewicht:
- 360.36
- MOL-Datei:
- 39562-70-4.mol
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Nitrendipin Eigenschaften
- Schmelzpunkt:
- 1580C
- Siedepunkt:
- 492.4°C (rough estimate)
- Dichte
- 1.3595 (rough estimate)
- Brechungsindex
- 1.5700 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- methanol: 15 mg/mL
- Aggregatzustand
- powder
- pka
- 2.79±0.70(Predicted)
- Farbe
- yellow to green
- Wasserlöslichkeit
- Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
- CAS Datenbank
- 39562-70-4(CAS DataBase Reference)
- NIST chemische Informationen
- Nitrendipine(39562-70-4)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
20/21/22 |
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| S-Sätze: |
36 |
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| WGK Germany |
1 |
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| RTECS-Nr. |
US5653000 |
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| Toxizität |
LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H312 |
Gesundheitsschädlich bei Hautkontakt. |
Akute Toxizität dermal |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P280,P302+P352, P312, P322, P363,P501 |
| H332 |
Gesundheitsschädlich bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P321 |
Besondere Behandlung |
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Nitrendipin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged
therapeutic effect in comparison to nifedipine makes it useful in the once to twice
daily treatment of hypertension.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t
e treatment of hypertension.
Allgemeine Beschreibung
Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.
Biologische Aktivität
L-type calcium channel blocker.
Nitrendipin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nitrendipin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 435)Lieferanten
39562-70-4(Nitrendipin)Verwandte Suche:
Nimodipin
Dimethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylat
Mexiletin
EPN
Pyridin-3,5-dicarbonsure
Nitrendipin
2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridin-3,5-dicarboxylat
Niludipin
2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid
- NITRENDIPINE
- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidethy
- baye5009
- bayotensin
- baypress
- ethylmethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxy
- 2，6-Dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester
- Bylotensin
- Deiten
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester (9CI)
- Nitrepin
- Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-ethyl 3-methyl ester
- 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester
- 3-ethyl 5-Methyl (4R)-2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Lercanidipine Ethyl Methyl Ester IMpurity (IMpurity 5)
- 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
- Nitrendipine for peak identification
- (RS)-Methylethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate
- lmethylester
- nidrel
- ylmethylester
- ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate
- 1,4-DIHYDRO-2,6-DIMETHYL-4-(3'-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER
- 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER
- NITRENDIPINE >95% CA2+ CHANNEL BLOCKER,
- NITRENDIPINE EPN(CRM STANDARD)
- (NITROPHENYLPYRIDINE ANALOGUE) EPN(CRM STANDARD)
- NITRENDIPINE IMPURITY AETHYL METHYL-2,6-DIMETHYL-4-(3-NITROPHENYL) PYRIDINE-3,5-DICARBOXYLATE
- NITRENDIPINE MM(CRM STANDARD)
- Nitrendipine, ≥95.0%
- Group horizon
- Nitrendipine for system suitability CRS
- Nitrendipine CRS
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Ethyl Methyl Ester
- Ethyl Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
- Nitrendipine USP/EP/BP
- Nitrendipiner
- Nitrendipine, Pharma
- Lercanidipine methyl ethyl ester imp
- Nitrendipine (BAY-E-5009)
- Nitrendipine Impurity1218
- Lercanidipine Ethyl Methyl Ester Impurity
- Nitrendipine D5Q: What is
Nitrendipine D5 Q: What is the CAS Number of
Nitrendipine D5 Q: What is the storage condition of
Nitrendipine D5
- NitrendipineQ: What is
Nitrendipine Q: What is the CAS Number of
Nitrendipine Q: What is the storage condition of
Nitrendipine Q: What are the applications of
Nitrendipine
- Nitrendipin
- 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Group of horizon
- 39562-70-4
- C18H20N2O6
- 36036
- Calcium Channel Modulators
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Ion Channels
- Inhibitors and Activators
