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(-)-BETA-HYDRASTINE

(-)-BETA-HYDRASTINE Struktur
118-08-1
CAS-Nr.
118-08-1
Englisch Name:
(-)-BETA-HYDRASTINE
Synonyma:
HYDRASTINE;l-hydrastine;Hydrastinebase;(-)-Hydrastine;quinolin-5-yl)-;(+/-)-Nor-β(-)--Hydrastine;(-)-B-HYDIASTINE;9S)-β-Hydrastine;(-)-β-Hydrastine
CBNumber:
CB2456153
Summenformel:
C21H21NO6
Molgewicht:
383.39
MOL-Datei:
118-08-1.mol
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(-)-BETA-HYDRASTINE Eigenschaften

Schmelzpunkt:
132℃
alpha 
D20 -50° (c = 0.3 in abs alc)
Siedepunkt:
510.32°C (rough estimate)
Dichte
1.339±0.06 g/cm3 (20 ºC 760 Torr)
Brechungsindex
1.5614 (estimate)
storage temp. 
−20°C
Löslichkeit
DMF: 10 mg/ml; DMSO: 10 mg/ml
Aggregatzustand
A crystalline solid
pka
7.8(at 25℃)
Wasserlöslichkeit
30mg/L(20 ºC)
CAS Datenbank
118-08-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 20/21/22
S-Sätze: 36
RIDADR  1544
WGK Germany  3
RTECS-Nr. MU6030000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2939800000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

(-)-BETA-HYDRASTINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

(-)-BETA-HYDRASTINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(-)-BETA-HYDRASTINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 75)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9341 55
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897
 sales@biopurify.com China 3424 58
Shaanxi Pioneer Biotech Co., Ltd . 		+8613259417953
 sales@pioneerbiotech.com China 3000 58
Antai Fine Chemical Technology Co.,Limited 		18503026267
 info@antaichem.com CHINA 9641 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
Aktin Chemicals, Inc. 		028-85159085
info@aktinchem.com CHINA 1025 58
Shaanxi Didu New Materials Co. Ltd 		+86-89586680 +86-13289823923
 1026@dideu.com China 9020 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32360 55

118-08-1()Verwandte Suche:

4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat Cevadin 6,7-Dimethoxy-3-(5,6,7,8-tetra-hydro-6-methyl-1,3-dioxolo(4,5-g)-isochinolin-5-yl)-1(3H)isobenzo-furanon-hydrochlorid, (S(R*,S*))- Hydrastininhydrochlorid Noscapin Noscapinhydrochlorid
  • HYDRASTINE, (-)-B-(P) (AHP Verified)
  • HYDRASTINE, (-)-B-(P)
  • Hydrastine (base and/or unspecified salts)
  • (1R,9S)-(-)-β-Hydrastine
  • (3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one
  • [R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one
  • (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
  • [S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one
  • 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one
  • 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one
  • (1R,9S)-B-hydrastine free base
  • Hydrastinebase
  • Hydrastine (10 mg)
  • l-beta-Hydrastine
  • l-hydrastine
  • Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-
  • phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso
  • quinolin-5-yl)-
  • HYDRASTINE
  • HYDRASTINE, (-)-B-
  • (-)-BETA-HYDRASTINE
  • (-)-B-HYDIASTINE
  • (1R,9S)-(-)-BETA-HYDRASTINE
  • (1R,9S)-BETA-HYDRASTINE
  • [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
  • 6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
  • HYDRASTINE (D-beta-)
  • (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE
  • 9S)-β-Hydrastine
  • N-Desmethyl &beta
  • (+/-)-Nor-&beta
  • 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-
  • (1R,9S)-(–)-β-Hydrastine
  • (-)-β-Hydrastine
  • (-)--Hydrastine
  • (-)-BETA-HYDRASTINE
  • Hydrastine (1313210)
  • (-)-Hydrastine
  • (S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one
  • Hydrastine,Inhibitor,inhibit
  • 118-08-1
  • XYLOCAINE
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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