IKARUGAMYCIN

36531-78-9

CAS-Nr.: 36531-78-9

Englisch Name:: IKARUGAMYCIN

Synonyma:: TU-6239 C3;IKARUGAMYCIN;turbinomycin;WSUGGLXIPUHOSG-XSYQVIBFSA-N;14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione;3-Ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-;14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-

CBNumber:: CB2754262

Summenformel:: C29H38N2O4

Molgewicht:: 478.62

MOL-Datei:: 36531-78-9.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 64

IKARUGAMYCIN Eigenschaften

Siedepunkt:: 741.9±60.0 °C(Predicted)

Dichte: 1.22±0.1 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: chloroform: soluble1mg/mL (requires heating and sonication)

Aggregatzustand: White to off-white crystalline solid.

pka: 4.50±1.00(Predicted)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
HS Code	29419000

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H301	Giftig bei Verschlucken.	Akute Toxizität oral	Kategorie 3	Achtung	src="/GHS06.jpg" width="20" height="20" />	P264, P270, P301+P310, P321, P330,P405, P501

Sicherheit

P301+P310

BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

IKARUGAMYCIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity. It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC₅₀ = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases. It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 μM. Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis.

Verwenden

Ikarugamycin is an unusual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes, with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrates selective Gram positive antibacterial activity, and anti-ucler activity possibly via inhibition of H. pylori. In addition, ikarugamycin inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and Nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful agent for studying the process of endocytosis.

Definition

ChEBI: A polyketide macrolactam containing a tetramic acid (2,4-pyrrolidine-2,4-dione) ring system. It is isolated from Streptomyces as an antibitoic with antiprotozoal and cytotoxic activities.

IKARUGAMYCIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

IKARUGAMYCIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 64)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15377	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	13119157289@163.com	China	2971	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58

36531-78-9()Verwandte Suche:

Cyclododecen

TU-6239 C3
IKARUGAMYCIN
14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione
3-Ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-
14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-
WSUGGLXIPUHOSG-XSYQVIBFSA-N
turbinomycin
36531-78-9
C29H4N2O4
C29H38N2O4
Antibiotic