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TALIPEXOLE

TALIPEXOLE Struktur
101626-70-4
CAS-Nr.
101626-70-4
Englisch Name:
TALIPEXOLE
Synonyma:
Domin;Talipexol;TALIPEXOLE;Talipexolum;Talipexolum [latin];Talipexol [spanish];TALIPEXOLE USP/EP/BP;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
CBNumber:
CB3153213
Summenformel:
C10H15N3S
Molgewicht:
209.31
MOL-Datei:
101626-70-4.mol
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TALIPEXOLE Eigenschaften

Siedepunkt:
364.6±37.0 °C(Predicted)
Dichte
1.167±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
Soluble in DMSO
Aggregatzustand
Powder
pka
7.22±0.20(Predicted)

Sicherheit

TALIPEXOLE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

Trademarks

Domin

TALIPEXOLE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TALIPEXOLE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 35)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167
 1026@dideu.com China 9126 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2127 70
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4863 58
LETOPHARM LIMITED +86-21-5821 5861
sales@letopharm.com China 2384 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 3501 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088
 3193328036@qq.com China 29796 68
Musechem +1-800-259-7612
info@musechem.com United States 4662 60

101626-70-4()Verwandte Suche:

Ethyl-2-methyl-4-oxo-6-pentylcyclohex-2-en-1-carboxylat
  • TALIPEXOLE
  • 5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine
  • Domin
  • 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
  • 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
  • Talipexol
  • Talipexol [spanish]
  • Talipexolum
  • Talipexolum [latin]
  • 6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
  • TALIPEXOLE USP/EP/BP
  • 4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
  • 101626-70-4
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