JZL 195
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- CAS-Nr.
- 1210004-12-8
- Englisch Name:
- JZL 195
- Synonyma:
- CS-1586;JZL 195;JZL-195;JZL 195;JZL195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
- CBNumber:
- CB32591530
- Summenformel:
- C24H23N3O5
- Molgewicht:
- 433.46
- MOL-Datei:
- 1210004-12-8.mol
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JZL 195 Eigenschaften
- Siedepunkt:
- 581.8±50.0 °C(Predicted)
- Dichte
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO: ≥5mg/mL at warmed
- pka
- 6.13±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
N |
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| R-Sätze: |
50 |
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| S-Sätze: |
61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gewässergefährdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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JZL 195 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-
arachidonoylglycerol (2-
AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC
50s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-
dependent inhibition of FAAH and MAGL
in vivo, consistent with a covalent mechanism of activation. The
in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-
3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-
AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB
1 agonists.
Verwenden
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
JZL 195 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
JZL 195 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 80)Lieferanten
- JZL 195
- 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
- 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
- CS-1586
- JZL-195;JZL 195;JZL195
- 1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
- 4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate
- Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
- 1210004-12-8
- Inhibitors
- API
