Fosinopril sodium
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- CAS-Nr.
- 88889-14-9
- Englisch Name:
- Fosinopril sodium
- Synonyma:
- MONOPRIL;DYNACIL;ELIDIUR;FOSINORM;Acecor-d5;Staril-d5;TENSOZIDE;Eosinopril;SQ 28555-d5;Secorvas-d5
- CBNumber:
- CB5110597
- Summenformel:
- C30H46NNaO7P
- Molgewicht:
- 586.65
- MOL-Datei:
- 88889-14-9.mol
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Fosinopril sodium Eigenschaften
- Schmelzpunkt:
- 196-198°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- H2O: >20mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- CAS Datenbank
- 88889-14-9(CAS DataBase Reference)
Fosinopril sodium Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fosinopril sodium, an ester prodrug of fosinoprilat, is the first of a new generation of
phosphinic acid ACE inhibitors indicated for the once-daily treatment of hypertension.
Unlike captopril and lisinopril, it is reportedly effective in increasing the left
ventricular peak filling rates and peak ejection rates in hypertensive patients at rest.
Another advantage is that fosinopril sodium is metabolized equally by renal and hepatic
routes, thereby avoiding the requirement to modify dosage in patients with renal
insufficiency.
Chemische Eigenschaften
White to Off-White Crystalline Solid
Verwenden
Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
Definition
ChEBI: The sodium salt of fosinopril. It is used for the treatment of hypertension and heart failure. A pro-drug, its phosphinate ester group is hydrolysed in vivo to give the corresponding phosphininc acid, fosinoprilat, which is the active metaboli
e.
Allgemeine Beschreibung
Fosinopril sodium, (4S)-4-cyclohexyl-1-[[[(RS)-1-hydroxy-2-methylpropoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline sodium salt (Monopril),is a phosphorus-containing ACE inhibitor. It is inactive butserves as a prodrug, being completely hydrolyzed by intestinaland liver enzymes to the active diacid fosinoprilat.
Fosinopril sodium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fosinopril sodium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 280)Lieferanten
88889-14-9()Verwandte Suche:
- sodiuM (2S,4S)-4-cyclohexyl-1-(2-((2-Methyl-1-(propionyloxy)propoxy)(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-carboxylate
- Sodium (2S,4S)-4-cyclohexyl-1-(2-((2-methyl-1-(propionyloxy)propoxy)-(4-phenylbutyl)phosphoryl)ac
- SQ 28555-d5
- Staril-d5
- Fosinopril sodiuM API
- Fosinopril-d7 sodiuM salt
- Acecor-d5
- Eosinopril-d5
- Monopril-d5
- Secorvas-d5
- (4S)-4-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline,sodium salt (1:1)
- (2S,4S)-4-Cyclohexyl-1-(2-{[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylic acid
- Fosinopril sodium (Monopril)
- Sodium (2S,4S)-4-cyclohexyl-1-(2-((2-methyl-1-(propionyloxy)propoxy)-(4-phenylbutyl)phosphoryl
- TENSOZIDE
- FOSINOPRIL-D5 SODIUM SALT
- FOSINOPRIL NA
- FOSINOPRIL SODIUM
- FOSINOPRIL SODIUM SALT
- FOSINORM
- DYNACIL
- ELIDIUR
- (4S)-4-CYCLOHEXYL-1-[[(R)-[(1S)-2-METHYL-1-(1-OXOPROPOXY)PROPOXY](4-PHENYLBUTYL)PHOSPHINYL]ACETYL]-L-PROLINE
- (4s)-4-cyclohexyl-1-{[(rs)-2-methyl-1-(propionyloxy)propoxy]-(4-phenylbutyl)phosphinylacetyl}-l-proline sodium salt
- Fosinopril Sodium (200 mg)
- (4S)-4-Cyclohexyl-1-[[(R)-[(1S)-2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline SodiuM Salt
- Eosinopril
- (4S)-4-Cyclohexyl-1-[[(R)-[(1S)-2-Methyl-1-(1-oxopropoxy)propoxy](4-(phenyl-d5)butyl)phosphinyl]acetyl]-L-proline SodiuM Salt
- Forsinopril sodium salt
- 4β-Cyclohexyl-1-[[[(S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline sodium salt
- Dynacil, Elidiur, Fosinorm, Monopril, Staril, Tensozide, (4S)-4-Cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline
- FOSINPRIL SODIUM
- sodium 4-cyclohexyl-1-[2-[[2-methyl-1-(1-oxopropoxy)propoxy]-(4-phenylbutyl)phosphoryl]-1-oxoethyl]-2-pyrrolidinecarboxylate
- fosinopril impurity 1
- Fosinopril sodium CRS
- Fosinopril sodium USP/EP/BP
- Fosinopril sodiumr
- Sodium (2S,4S)-4-cyclohexyl-1-(2-((R)-((S)-2-methyl-1-(propionyloxy)propoxy)(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-carboxylate
- Fosinopril Sodium (SQ28555)
- Fosinopril sodiumQ: What is
Fosinopril sodium Q: What is the CAS Number of
Fosinopril sodium Q: What is the storage condition of
Fosinopril sodium Q: What are the applications of
Fosinopril sodium
- MONOPRIL
- 88889-14-9
- C30H46NO7PNa
- C30H45NO7PNa
- C30H45NNaO7P
- 58564
- Cardiovascular APIs
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Aromatics
- Chiral Reagents
- Phosphorylating and Phosphitylating Agents
- Isotope Labelled Compounds
- API
