4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl

4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

Beschreibung

TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP₅₀) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED₅₀s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.

Chemische Eigenschaften

solid

Verwenden

A free radical scavenger

Application

In biochemical research, 4-hydroxy-TEMPO has been investigated as an agent for limiting reactive oxygen species.  It catalyzes the disproportionation of superoxide, facilitates hydrogen peroxide metabolism, and inhibits Fenton chemistry.4-Hydroxy-TEMPO, along with related nitroxides, are being studied for their potential antioxidant properties.On an industrial-scale 4-hydroxy-TEMPO is often present as a structural element in hindered amine light stabilizers, which are commonly used stabilizers in plastics, it is also used as a polymerisation inhibitor, particularly during the purification of styrene. 

Allgemeine Beschreibung

4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic.

Biologische Aktivität

Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects.

4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jiangxi Lotchem Co.,Ltd.	+8615270827708	lancetu@jxlotchem.com	CHINA	338	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58
ZHEJIANG ESTCHEM CO.,LTD	15957180504	sales@zjestchem.com	China	193	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15962	58
Dalian Richfortune Chemicals Co., Ltd	0411-84820922 8613904096939	sales@richfortunechem.com	China	304	57
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60

2226-96-2(4-Hydroxy-2,2,6,6-tetramethylpiperidinoxyl)Verwandte Suche:

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• 4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL
• 4-HYDROXY-2,2,6,6-TETRAMETHYL-PIPERIDINOOXY
• 4-HYDROXY-2,2,6,6-TETRAMETHYL-1-PIPERIDIN-1-YLOXY
• 4-HYDROXY-2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY, FREE RADICAL
• 4-HYDROXY-2,2,6,6-TETRAMETHYL-PIPERIDINOOXY, FREE RADICAL
• 4-HYDROXY-TEMPO, FREE RADICAL
• 2,2,6,6-Tetramethyl-4-hydroxypiperidine 1-oxyl
• 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical
• 4-Hydroxy-TEMPO Styrene,Acrylates+Acrylics polymerisation inhibitor
• 2,2,6,6-TETRAMETHYL-4-HYDROXY-1-PIPERIDINYLOXY
• 2,2,6,6-TETRAMETHYL-4-PIPERIDINOL 1-OXYL
• 2,2,6,6-Tetramethyl-4-piperidinol-1-oxide
• 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl(4-Hydroxy-TEMPO,freeradical)
• 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-
• 4-HYDROXY-2,2,6,6-TETRAMETHYL-PIPERIDINYLOXY (TMHPO .)
• 4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL(4-HYDROXYTEMPO)
• Dipyridamole oxide
• 4-Hydroxy-2,2,6,6-tetramethyl piperidinyloxy free
• 4-HYDROXY-2,2,6,6-TETRAMETHYL-1-PIPERIDIN-1-YLOXY / 4-HYDROXY-TEMPO, FREE RADICAL
• 2,2,6,6-TetraMethyl-4-hydroxy-1-piperidinyloxy Radical
• Alcoholpiperidine nitroxides
• 4-Hydroxy-TEMPO 97%
• Piperidol oxide
• 2,2,6,6-Tetramethyl-4-piperidinol 1-oxyl, free radical
• 4-Hydroxy-2,2,6,6-tetramethylpiperidineN-oxide≥ 99% (GC)
• SUBSTITUTED PIPERIDINYLOXY PYRAZINYL DER
• 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (free radical) for synthesis
• 2,2,6,6-Tetramethyl-4-hydroxypiperidin-1-oxyl
• 2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy
• 2,2,6,6-Tetramethyl-4-hydroxypiperidinooxy radical
• 2,2,6,6-Tetramethyl-4-hydroxypiperidyl 1-oxyl
• 2,2,6,6-Tetramethyl-4-oxypiperidine-1-oxyl
• 2,2,6,6-Tetramethyl-4-piperidinol nitroxide
• 2,2,6,6-Tetramethyl-4-piperidinol N-oxyl
• 2,2,6,6-Tetramethyl-4-piperidinol-1-oxy
• 2,2,6,6-tetramethyl-4-piperidinol-n-oxyl
• 2,2,6,6-Tetramethyl-4-piperindiol 1-oxyl
• 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-ol
• 2,2,6,6-Tetramethylpiperidinol-4-oxyl-1
• 1-Oxyl-2,2,6,6-tetramethyl-4-piperidinol
• 2,2,4,4-Tetramethyl-4-Piperidinol N-oxide
• 2,2,6,6-Tetramethyl-1,4-piperidinediol
• 4-Hydroxy-2,2,6,6-tetramethyl-piperidine1-oxide
• 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxy
• 4-hydroxy-2,2,6,6-tetramethyl-piperidinoox
• 4-Hydroxy-2,2,6,6-tetramethylpiperidinooxy radical
• 4-hydroxy-2,2,6,6,-tetramethylpiperimyloxy
• 4-hydroxy-2,2,6,6-tetramethyl-1-piperidinylox
• 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy
• 4-Hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxide
• 4-Hydroxyl-2,2,6,6-tetramethyl-piperidin-1-oxyl free radical
• 4-Hydroxy-2,2,6,6,- tetramethyl-4-piperidinyloxide,free radical
• 4-HYDROXY TEMPO, FREE RADICAL HPLC 99.8%
• 2,2,6,6-Tetramethyl freeagaoxy-4-piperidyl
• 4-Hydroxy-2,2,6,6-tetramethylpiperidinooxyl
• 4-Hydroxy-2,2,6,6-tetramethylpiperidinoxy
• 4-Hydroxy-2,2,6,-tetramethylpiperidyl-1-oxy
• 4-Hydroxy-2,2,6,-tetramethylpiperidyl-1-oxyl