Diloxanid

diloxanide Struktur
579-38-4
CAS-Nr.
579-38-4
Bezeichnung:
Diloxanid
Englisch Name:
diloxanide
Synonyma:
RD3803;RD 3803;RD-3803;Diloxanid;diloxanide;Diloxanida;diloxanide USP/EP/BP;α,α-Dichloro-4'-hydroxy-N-methylacetanilide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide;2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide
CBNumber:
CB5875447
Summenformel:
C9H9Cl2NO2
Molgewicht:
234.08
MOL-Datei:
579-38-4.mol

Diloxanid Eigenschaften

Schmelzpunkt:
175°
Siedepunkt:
356.2±42.0 °C(Predicted)
Dichte
1.439±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMSO:33.33(Max Conc. mg/mL);142.39(Max Conc. mM)
pka
9.95±0.15(Predicted)

Sicherheit

Diloxanid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Diloxanide is also active against cysts and trophozoites localized in the lumen of the intestine, and it is used for treating the carrier E. histolytica, as well as for treating asymptomatic or moderate forms of amebiasis. In the transition stage to trophozoites, the drug is less active than iodoquinol. A synonym of this drug is furamide.

Antimicrobial activity

Diloxanide inhibits E. histolytica with unusually high specificity at concentrations of 0.01–0.1 mg/L.

Acquired resistance

No resistance has been reported. Patients with dysentery have lower cure rates than cyst excreters.

Pharmazeutische Anwendungen

Dichloro(hydroxyphenyl)methylacetamide. Available as an insoluble ester, the furoate, for oral administration.

Pharmakokinetik

Human pharmacokinetic data are limited. Animal data show that diloxanide furoate is rapidly absorbed from the intestine. The furoate is hydrolyzed in the gut, leaving high intraluminal concentrations of free diloxanide. About 75% is excreted via the kidney within 48 h, mostly as a glucuronide.

Clinical Use

Furamide, or eutamide, is the 2-furoate ester of 2,2-dichloro-4 -hydroxy-N-methylacetanilide. It was developed as a resultof the discovery that various α,α-dichloroacetamidespossessed amebicidal activity in vitro. Diloxanide itself andmany of its esters are also active, and drug metabolism studiesindicate that hydrolysis of the amide is required for theamebicidal effect. Nonpolar esters of diloxanide are morepotent than polar ones. Diloxanide furoate has been used inthe treatment of asymptomatic carriers of E. histolytica. Itseffectiveness against acute intestinal amebiasis or hepaticabscesses, however, has not been established. Diloxanidefuroate is a white crystalline powder. It is administered orallyonly as 500-mg tablets and may be obtained in the UnitedStates from the CDC in Atlanta, Georgia.

Nebenwirkungen

It is well tolerated, but flatulence is common, and nausea and vomiting may occur.

Diloxanid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diloxanid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 28)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004
1015@dideu.com China 2263 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 28557 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 9020 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43348 58
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
sales@hopschem.com China 31557 55
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720
psaitong@jm-bio.com China 12308 58
Wuhan FengyaoTonghui Chemical Products Co., Ltd. 027-87466105 15377573527
2678564200@qq.com China 17997 58

579-38-4(Diloxanid)Verwandte Suche:


  • diloxanide
  • α,α-Dichloro-4'-hydroxy-N-methylacetanilide
  • 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
  • 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-acetamide
  • 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-ethanamide
  • Acetamide, 2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl-
  • diloxanide USP/EP/BP
  • Diloxanid
  • Diloxanida
  • RD 3803
  • RD3803
  • RD-3803
  • infection,inhibit,Entamoeba histolytica,anti-protozoal,Parasite,amoebic colitis,Diloxanide,Inhibitor,luminal amebicide
  • 579-38-4
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