1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE

112037-78-2

CAS-Nr.: 112037-78-2

Englisch Name:: 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE

Synonyma:: -carboline;3-Methyl αNorharmane (9H-Pyrido[3,4-b]indole, ß1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ßrac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-β1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline;1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE;1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE;1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline

CBNumber:: CB6140573

Summenformel:: C12H11F3N2

Molgewicht:: 240.22

MOL-Datei:: 112037-78-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 13

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Eigenschaften

Schmelzpunkt:: 147-149°C

Siedepunkt:: 350.0±37.0 °C(Predicted)

Dichte: 1.351±0.06 g/cm3(Predicted)

pka: 16.63±0.40(Predicted)

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26-36/37/39

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Mechanism of action

Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.

Clinical Use

Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1-Ethoxy-2,2,2-trifluorethanol 2-(Indol-3-yl)ethylamin

Downstream Produkte

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 13)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hangzhou Yuhao Chemical Technology Co., Ltd	0571-82693216	info@yuhaochemical.com	China	9394	52
United States Biological	--	sales@advtechind.com	United States	6106	58

-carboline
1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline
1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ß
1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline
1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE
(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta
rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta
3-Methyl &alpha
1-trifluoromethyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole
Norharmane (9H-Pyrido[3,4-b]indole, ß
1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-(trifluoromethyl)-
2,3,4,9-Tetrahydro-1-(trifluoromethyl)-1H-pyrido[3,4-b]indole
112037-78-2
pharmacetical