U-73122
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- CAS-Nr.
- 112648-68-7
- Englisch Name:
- U-73122
- Synonyma:
- U-73312;U-73122;CS-1793;CS-2400;U-73122 98%;U 73122;U-73122;U-73122 hydrate;U-73122 USP/EP/BP;U-73122 hydrate(U73122);U-73122 - CAS 112648-68-7 - Calbiochem
- CBNumber:
- CB6237598
- Summenformel:
- C29H40N2O3
- Molgewicht:
- 464.64
- MOL-Datei:
- 112648-68-7.mol
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U-73122 Eigenschaften
- Siedepunkt:
- 617.1±55.0 °C(Predicted)
- Dichte
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- ethanol: 0.7 mg/mL
- Aggregatzustand
- solid
- pka
- 10.69±0.40(Predicted)
- Farbe
- off-white
- Wasserlöslichkeit
- Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml. May require heating or overnight mixing. Insoluble in water
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Use caution when storing DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that turn pink should be discarded.
U-73122 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
U-
73122 is an inhibitor of PLC-
dependent processes, however, the mechanism of action remains unclear. The IC
50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 μM, respectively. It also exhibits inhibitory activity against HIV-
1 integrase with an IC
50 value of 7 μM.
Verwenden
It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
Definition
ChEBI: An aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C.
Biologische Aktivität
Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC 50 values of 1-5 μ M. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC 50 < 50 nM) and exhibits antinociceptive activity in vivo .
U-73122 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
U-73122 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 104)Lieferanten
112648-68-7()Verwandte Suche:
- U-73122
- 1-[6-[[(17B)-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL]AMINO]HEXYL]-1H-PYRROLE-2,5-DIONE
- 1-[6-((17BETA-3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL]-1H-PYRROLE-2,5-DIONE
- U-73122 98%
- 1-[6-[((17β)-3-methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1h-pyrrole-2,5-dione
- U-73122 hydrate
- (17β)-3-Methoxy-17-[6-[(2,5-dihydro-2,5-dioxo-1H-pyrrol)-1-yl]hexylamino]estra-1,3,5(10)-triene
- 1-[6-[[3-Methoxyestra-1,3,5(10)-triene-17β-yl]amino]hexyl]-1H-pyrrole-2,5-dione
- U-73312
- 1-(6-((3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
- 1H-Pyrrole-2,5-dione, 1-(6-(((17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-
- 1-(6-((8R,9S,13S,14S,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ylamino)hexyl)-1H-pyrrole-2,5-dione
- 1-[6-[[(17beta)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione U73122
- U-73122 hydrate(U73122)
- U-73122 - CAS 112648-68-7 - Calbiochem
- CS-1793
- U 73122;U-73122
- CS-2400
- 1H-Pyrrole-2,5-dione, 1-[6-[[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-
- U-73122 USP/EP/BP
- 112648-68-7
- 12648-68-7
- C29H40N2O3xH2O
- Biochemicals and Reagents
- BioChemical
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Phospholipase A 2
- P to Q
- Lipid signaling
- Inhibitors
