Amitrol (ISO) Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
GERUCHLOSE FARBLOSE KRISTALLE.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Stickstoffoxiden. Schwache Base. Reagiert mit starken Säuren, starken Oxidationsmitteln, Säurechloriden und Säureanhydriden. Greift Eisen, Kupfer und Aluminium an.
ARBEITSPLATZGRENZWERTE
TLV: 0,2 mg/m?(als TWA); Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK: 0,2 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor II(8); Krebserzeugend Kategorie 3B; Schwangerschaft: Gruppe C; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Möglich sind Auswirkungen auf die Schilddrüse.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglich sind Auswirkungen auf die Schilddrüse mit nachfolgender Kropfbildung.
LECKAGE
NICHT in die Kanalisation spülen. Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P3-Filter für giftige Partikel.
R-Sätze Betriebsanweisung:
R48/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S13:Von Nahrungsmitteln, Getränken und Futtermitteln fernhalten.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
white powder or crystals
Verwenden
catalase inhibitor
Definition
A powerful plant growth
suppressant and cotton defoliant that is readily
absorbed by leaves and roots. 3-Amino-1,2,4-Triazole inhibits many
aspects of growth and differentiation including cell
division in the primary root meristems in some
plants.
Vorbereitung Methode
3-Amino-1,2,4-Triazole（Amitrole） is synthesized by condensing formic acid with
aminoguanidine and can be purified by recrystallization
from methanol.
Allgemeine Beschreibung
Odorless white crystals or white powder. Bitter taste. Melting point 147-159°C. Sublimes undecomposed at reduced pressure. Used as a post-emergence herbicide.
Air & Water Reaktionen
Water soluble. Aqueous solutions are neutral. Dust may form an explosive mixture in air.
Reaktivität anzeigen
3-Amino-1,2,4-Triazole is a triazole derivative. The triazoles are a group that contain several derivatives that are highly explosive materials. They are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazol ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. It forms chelates with some metals. 3-Amino-1,2,4-Triazole is corrosive to iron, copper and aluminum. Forms salts with most acids and alkalis. It is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides .
Hazard
Toxic; carcinogen.
Health Hazard
Amitrole (3-Amino-1,2,4-Triazole) has low acute toxicity;
in experimental animal studies subchronic
exposures were associated with changes in the
thyroid and chronic exposures were
carcinogenic.
Intentional ingestion of a mixture that contained
20 mg/kg amitrole did not cause any
signs of intoxication.1 In one reported case
study, inhalation of a large amount of amitrolecontaining
herbicide was associated with acute
toxic reaction of the lungs.2 Lung injury was
thought to be secondary to direct toxic damage
to the alveolar lining cells. The remarkable lack
of any other reports describing pulmonary toxicity
of this herbicide was noted, in addition to
the presence of other chemicals in the herbicide
solution.
Brandgefahr
Literature sources indicate that Triazol-3-amine is non-combustible.
Landwirtschaftliche Anwendung
Herbicide, Plant growth regulator: A non-food use herbicide for control of grasses,
woody plants and broad-leaf weeds on hard surface and in
areas where crops are not normally grown.
Handelsname
AMITRIL®; ATLAZIN®; ATLAZINE®
FLOWABLE; AT®; 3-AT®; AT-90®; ATRAFLOW PLUS®;
AZAPLANT®; AZAPLANT KOMBI®; AZOLAN®;
AZOLE®; BOROFLOW® A/ATA; CAMPAPRIM® A
1544; CDA SIMFLOW PLUS®; CHIPMAN® PATH;
CYTROLE®; DIUROL® AMITROLE; DOMATOL®;
ELMASIL®; EMISOL®; FARMCO®; HERBAZIN PLUS
SC®; HERBICIDE® TOTAL; MASCOT HIGHWAY®;
MSS AMINOTRIAZOLE®; MSS SIMAZINE®;
ORGA-414®; RADOXONE® TL; RAMIZOL®;
RASSAPRON®; SIMAZOL®; SIMFLOW PLUS®;
SOLUTION CNCENTREE T271®; SYNCHEMICALS®
TOTAL WEED KILLER; SYNTOX®; TORAPRON®;
VOROX®; WEEDAR®; WEEDAZIN®; WEEDAZOL TL
®; WEEDOCLOR®
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. An herbicide and plant growth regulator
mögliche Exposition
A potential danger to those involved
in the manufacture, formulation, and application of this
postemergence herbicide, which is now limited to noncrop
applications as a herbicide and plant growth regulator.
Some triazoles have been used as rubber components.
Carcinogenicity
Amitrole is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
Soil. When radiolabeled amitrole-5-14C was incubated in a Hagerstown silty clay loam,
50 and 70% of the applied amount evolved as 14CO2 after 3 and 20 days, respectively. In
autoclaved soil, however, no 14CO2 was detected. The chemical degradation in soil was
probably via hydroxyl radicals (Kaufman et al., 1968). The average persistence in soils is
2–4 weeks (Hartley and Kidd, 1987)
Plant.Amitrole is transformed in plants to form the conjugate β-(3-amino-1,2,4-triazol-
1-yl)-α-alanine (Humburg et al., 1989) and/or 3-(3-amino-s-triazole-1-yl)-2-aminopropionic acid (Duke et al., 1991). Amitrole is metabolized in Canada thistl
Surface Water. In pond water, adsorption to suspended sediments was an important
process. The initial half-life was reported to be no more than 68 days. After 120 days,
20% of the applied amount remained (Grzenda et al., 1966). The biodegradation
Photolytic. Direct photolysis of amitrole is not expected to occur since the herbicide
shows little or no absorption greater than 295 nm (Gore et al., 1971)
Chemical/Physical. Reacts with acids and bases forming soluble salts (Hartley and
Kidd, 1987). Emits toxic fumes of nitrogen oxides when heated to decomposition (Sax
and Lewis, 1987); however, incineration with polyethylene results in more than 9
Versand/Shipping
UN2588 Pesticides, solid, toxic, Hazard Class:
6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous
material, Technical Name Required.
läuterung methode
It crystallises from EtOH (charcoal), then three times from dioxane [Williams et al. J Phys Chem 61 261 1957]. [Beilstein 26 H 137.] Possible carcinogen. [Beilstein 26 H 137, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.]
Inkompatibilitäten
Dust may be explosive in air. Keep
away from strong oxidizers; strong acids; light and heat
(decomposes). Corrosive to iron, aluminum, and copper.
Sublimes undecomposed at reduced pressure.
Waste disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Amitrol is resistant to hydrolysis and the action of oxidizing
agents. Burning the compound with polyethylene is
reported to result in .99% decomposition.
Amitrol (ISO) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Trapidil
2-Hydroxy-N-1H-1,2,4-triazol-3-ylbenzamid
3-Chlor-1H-1,2,4-triazol
1-(TERT-BUTYL)-1H-1,2,4-TRIAZOL-3-AMINE
4H-1,2,4-Triazol-3-amine, 4-[(4-chlorophenyl)methyl]-
7-amino[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile(SALTDATA: FREE)
1-(7-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-6-YL)-1-ETHANONE
1H-1,2,4-Triazole-1-carboxamide,2-amino-N-methyl-(9CI)
7-phenyl-4H,5H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one
