4-Hydroxy-3-methoxyphenylessigsure
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- CAS-Nr.
- 306-08-1
- Bezeichnung:
- 4-Hydroxy-3-methoxyphenylessigsure
- Englisch Name:
- Homovanillic acid
- Synonyma:
- HVA;Homovanilic acid;4-HYDROXY-3-METHOXYPHENYLACETIC ACID;4-Hydroxy-3-methoxybenzeneacetic acid;Benzeneacetic acid, 4-hydroxy-3-methoxy-;JACS-306-08-1;homovanillicaci;Vanilacetic acid;HOMOVANIUIC ACID;HOMORANILLIC ACID
- CBNumber:
- CB7198081
- Summenformel:
- C9H10O4
- Molgewicht:
- 182.17
- MOL-Datei:
- 306-08-1.mol
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4-Hydroxy-3-methoxyphenylessigsure Eigenschaften
- Schmelzpunkt:
- 142-145 °C(lit.)
- Siedepunkt:
- 235.56°C (rough estimate)
- Dichte
- 1.1634 (rough estimate)
- Brechungsindex
- 1.4209 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Heated)
- Aggregatzustand
- Crystalline Powder
- pka
- 4.39±0.10(Predicted)
- Farbe
- White to beige
- Wasserlöslichkeit
- soluble
- Merck
- 14,4740
- BRN
- 2213447
- Stabilität:
- Hygroscopic
- LogP
- 0.330
- CAS Datenbank
- 306-08-1(CAS DataBase Reference)
- NIST chemische Informationen
- Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1)
- EPA chemische Informationen
- Homovanillic acid (306-08-1)
4-Hydroxy-3-methoxyphenylessigsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Homovanillic acid (HVA) is a dopamine metabolite. It is formed
via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.
Chemische Eigenschaften
white to beige crystalline powder
Verwenden
Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.
Definition
ChEBI: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Biologische Aktivität
Fluorimetric reagent and major catecholamine metabolite. Used for fluorimetric determination of oxidative enzymes including glucose oxidase.
4-Hydroxy-3-methoxyphenylessigsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Hydroxy-3-methoxyphenylessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 391)Lieferanten
306-08-1(4-Hydroxy-3-methoxyphenylessigsure)Verwandte Suche:
- 4-hydroxy-3-methoxy-benzeneaceticaci
- 4-hydroxy-3-methoxy-Benzeneaceticacid
- Acetic acid, (4-hydroxy-3-methoxyphenyl)-
- Homovanillinic acid
- Vanilacetic acid
- Vanillacetic Acid
- RARECHEM AL BO 0135
- 4-HYDROXY-3-METHOXYPHENYLACETIC
- HOMORANILLIC ACID
- HomovanillicAcid98%
- 3-METHOXY-4-HYDROXYPHENYL ACETIC ACID
- HOMOVANIUIC ACID
- HOMOVANILLIC ACID
- Homovanillic acid 4-Hydroxy-3-methoxyphenylacetic acid
- 2-(4-hydroxy-3-methoxy-phenyl)acetic acid
- HOMOVANILLIC ACID(RG)
- Benzeneaceticacid,4-hydro
- 4-HYDROXY-3-METHOXYPHENYLACETIC ACID (HOMOVANILLIC ACID)
- HOMOVANILLIC ACID extrapure
- 4-Hydroxy-3-methoxyphenylacetic acid, HVA
- 3-Methoxy-4-hydroxybenzeneacetic acid
- Homovanillic acid,4-Hydroxy-3-methoxyphenylacetic acid, HVA
- 4-Hydroxy-3-Methoxy-α-toluic acid
- HoMoprotocatechuic acid 3-Methyl ether
- HoMovanillic acid, 98% 1GR
- Homovanillic acidFluorimetric reagent≥ 99% (GC)
- 2-(4-hydroxy-3-methoxyphenyl)acetate
- JACS-306-08-1
- 4-Hydroxy-3-methoxyphenylaceticAcid>
- homovanillicaci
- 4-Hydroxy-3-methoxy-α-toluic acid
- Homovanillic acid 306-08-1
- 4-Hydroxy-3-methoxybenzeneacetic acid
- Homovanilic acid
- 4-HYDROXY-3-METHOXYPHENYLACETIC ACID
- HVA
- Benzeneacetic acid, 4-hydroxy-3-methoxy-
- Dopamine Impurity 81 (Homovanillic Acid)
- 306-08-1
- HOC6H3OCH3CH2CO2H
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Multisubstituted Benzene
- Pharmaceutical Intermediates
- Aromatics
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
