5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
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- CAS-Nr.
- 648450-29-7
- Englisch Name:
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- Synonyma:
- AS605240;AS-605240, >=98%;AS-605240(AS 605240);PI 3-Kinase Inhibitor (AS605240);PI 3-Kγ Inhibitor AS-605240 AS605240;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, 98%, a specific inhibitor of PI3Kγ;PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem;5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- CBNumber:
- CB72100624
- Summenformel:
- C12H7N3O2S
- Molgewicht:
- 257.27
- MOL-Datei:
- 648450-29-7.mol
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5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Eigenschaften
- Dichte
- 1.553±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble1mg/mL, clear (warmed)
- pka
- 6.02±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- , faint red to orange to dark brown
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
AS605240 has been used:
- as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
- as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
- as a class 1A PI3K inhibitor?to treat CD4+?T cells.
Biologische Aktivität
Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
Biochem/physiol Actions
AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 135)Lieferanten
648450-29-7()Verwandte Suche:
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- AS605240
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
- PI 3-Kinase Inhibitor (AS605240) B-0301
- AS-605240, >=98%
- (E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione
- 2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-
- AS-605240(AS 605240)
- (Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione AS-605240
- AS-605240
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- AS-605240, 98%, a specific inhibitor of PI3Kγ
- PI 3-Kinase Inhibitor (AS605240)
- AS 605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
- PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione USP/EP/BP
- 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- PI 3-Kγ Inhibitor AS-605240 AS605240
- 648450-29-7
- 348450-29-7
- Inhibitors
- API
- Akt
- mTOR
- PI3K
