5-Sulfamoyl-o-anissure
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- CAS-Nr.
- 22117-85-7
- Bezeichnung:
- 5-Sulfamoyl-o-anissure
- Englisch Name:
- 2-Methoxy-5-sulfamoylbenzoic acid
- Synonyma:
- Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
- CBNumber:
- CB7354418
- Summenformel:
- C8H9NO5S
- Molgewicht:
- 231.23
- MOL-Datei:
- 22117-85-7.mol
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5-Sulfamoyl-o-anissure Eigenschaften
- Schmelzpunkt:
- 220 °C
- Siedepunkt:
- 482.5±55.0 °C(Predicted)
- Dichte
- 1.492±0.06 g/cm3(Predicted)
- storage temp.
- Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 3.56±0.10(Predicted)
- Farbe
- White to Off-White
- CAS Datenbank
- 22117-85-7(CAS DataBase Reference)
5-Sulfamoyl-o-anissure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
synthetische
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
5-Sulfamoyl-o-anissure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Sulfamoyl-o-anissure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 166)Lieferanten
22117-85-7(5-Sulfamoyl-o-anissure)Verwandte Suche:
- 2-METHOXY-5-SULFAMOYLBENZOIC ACID
- 2-METHOXY-5-SULFONYLBENZOIC ACID
- 2-METHOXY-5-SULPHAMOYLBENZOIC ACID
- 3-CARBOXY-4-METHOXY-BENZENE SULFONAMIDE
- 2-Methoxy-5-Sufamoyl Benzoic Acid
- 5-Aminosulfonyl-2-Methoxybenzoic Acid
- 5-sulphamoyl-o-anisic acid
- 5-(Aminosulphonyl)-2-methoxybenzoic acid
- 2-METHOXY-5-SULFONAMIDOBENZOIC ACID
- 3-Carboxy-4-methoxybenzenesulphonamide
- 2-Methoxy-5-sulfaMidobenzoic Acid
- 5-SulfaMoyl-o-anisic Acid
- 2-METHOXY-5-SULFAMOYLBENZOIC ACIDSULPIRIDE
- Sulpiride IMpurity D
- 3-Carboxy-4-methoxybenzenesulphonamide, 5-(Aminosulphonyl)-o-anisic acid
- Benzoic acid,5-(aMinosulfonyl)-2-Methoxy-
- carbazole2-Methoxy-5-sulfamoylbenzoic acid
- Sulpiride Impurity D(EP)
- 6-methoxy-3-sulfonyl-1-cyclohexa-1,5-dienecarboxylic acid
- Sulpiride Impurity 4（Sulpiride EP Impurity D）
- Sulpiride EP Impurity D
- Levosulpiride - EP Impurity D
- 5-[(Aminoperoxy)thio]-2-methoxybenzoic Acid
- 2-Methoxy-5-sulfamoylbenzoicaci
- Sulpride Impurity D
- 22117-85-7
- C8H8NO5S
- Organic acids
- Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
