1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin
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- CAS-Nr.
- 28289-54-5
- Bezeichnung:
- 1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin
- Englisch Name:
- 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
- Synonyma:
- MPTP;NSC 139654;Naphthoic Acid Impurity 111;1-METHYL-4-PHENYL-PIPERIDINE-3-EN;1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin;1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine;1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE;1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE;N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
- CBNumber:
- CB8254906
- Summenformel:
- C12H15N
- Molgewicht:
- 173.25
- MOL-Datei:
- 28289-54-5.mol
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1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin Eigenschaften
- Schmelzpunkt:
- aprox. 36°C
- Siedepunkt:
- 128-132 °C12 mm Hg(lit.)
- Dichte
- 1.001±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- pka
- 8.66±0.40(Predicted)
- Farbe
- Pale Yellow to Light Yellow
- Merck
- 13,6319
- Stabilität:
- Stable. Incompatible with strong oxidizing agents.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25-39/23/24/25 |
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| S-Sätze: |
45 |
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| RIDADR |
UN 2811 6.1/PG 2 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UT8358900 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| Giftige Stoffe Daten |
28289-54-5(Hazardous Substances Data) |
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| Toxizität |
Human toxicity
originally discovered when it was an unexpected by-product
from the illicit synthesis of a heroin substitute (i.e., meperidine
analog). Currently used experimentally as the primary animal
model for the study of Parkinson’s disease. MPTP is a neurotoxicant
that is activated to 1-methyl-4-phenylpyridinium ion
(MPP1) by the actions of monoamine oxidase B located in the
mitochondria of brain astrocytes. The MPP1 is then transported
into dopamine, and to a lesser extent, other monoaminergic
neurons. Once inside these dopamine neurons in the
substantia nigra, it destroys these neurons by mechanisms that
may involve an oxidative cascade and/or inhibition of electron
transport. Intoxication causes a parkinsonism syndrome almost
identical in signs and symptoms to Parkinson’s disease, including
rigidity, bradykinesia, tremor, and postural instability. In
the event of known ingestion, immediate (but not delayed)
administration of a monoamine oxidase inhibitor (especially
one selective for MAO-B like deprenyl) and dopamine uptake
inhibitor can be therapeutic. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H370 |
Schädigt die Organe. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P307+P311 |
BEI Exposition: GIFTINFORMATIONSZENTRUM oder Arzt anrufen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Light Yellow Solid
Verwenden
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
Definition
ChEBI: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Stoffwechselwegen
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
in a rat pheochromocytoma cell line is oxidized to give
the N-methyl-4-phenylpyridinium ion.
1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 60)Lieferanten
28289-54-5(1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin)Verwandte Suche:
2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridin
2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridin
2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridin,(R-(R*,R*))-2,3-dihydroxy-butandioat (1:1)
2,3-Dihydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridinhydrobromid
1,2,3,6-Tetrahydro-1-methyl-4-phenylpyridin
- MPTP
- 1,2,3,6-tetrahydro-1-methyl-4-phenyl-pyridin
- 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)ochloride
- NSC 139654
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base
- Pyridine,1,2,3,6-tetrahydro-1-methyl-4-phenyl-
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin
- 1-METHYL-4-PHENYL-PIPERIDINE-3-EN
- 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
- 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE
- 1-METHYL-4-PHENYL-1,2,3,6-TETRA-*HYDROPY RIDINE FREE
- N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDRO-PYRIDINE
- MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
- C12H15N 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROXPYRIDINE 28289-54-5
- Naphthoic Acid Impurity 111
- 28289-54-5
- 8289-54-5
- Building Blocks
- C9 to C46
- Heterocyclic Building Blocks
- Pyridines
- Neurochemicals
- Heterocyclic Compounds
