Doxercalciferol
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- CAS-Nr.
- 54573-75-0
- Englisch Name:
- Doxercalciferol
- Synonyma:
- C08211;TSA 840;1α-OHD2;Hectorol;ERCALCIDOL;1ALPHA-OH-D2;Doxecalciferol;Doxercalcifero;Doxercalciferol;Doxercalciferol d6
- CBNumber:
- CB8394169
- Summenformel:
- C28H44O2
- Molgewicht:
- 412.65
- MOL-Datei:
- 54573-75-0.mol
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Doxercalciferol Eigenschaften
- Schmelzpunkt:
- 138-140°C
- Siedepunkt:
- 538.7±50.0 °C(Predicted)
- Dichte
- 1.01±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- White crystalline solid
- pka
- 14.43±0.40(Predicted)
- Farbe
- White to Almost white
- InChIKey
- HKXBNHCUPKIYDM-CGMHZMFXSA-N
- SMILES
- [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@H](C)/C=C/[C@H](C)C(C)C)/C(=C)[C@@H](O)C1
- CAS Datenbank
- 54573-75-0(CAS DataBase Reference)
- EPA chemische Informationen
- Doxercalciferol (54573-75-0)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T+ |
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| R-Sätze: |
28 |
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| S-Sätze: |
28-36/37-45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
VS2950000 |
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| HS Code |
2936299055 |
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| Toxizität |
LD50 orally in rats: 3.5-6.5 mg/kg (Sjden) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizität oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Doxercalciferol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as
Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients
with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha-
D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in
5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the
liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile
similar to calcitriol. During placebo-controlled clinical trials, patients with
moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to
24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were
considerably reduced, so maintaining a good control of the parathyroid
hyperplasia. Moreover, only a moderate tendency to raise calcium and
phosphate was observed. Doxercalciferol is orally-active and less toxic than
other vitamin D analogs like alfacalcidol; it shows differentially controlled effects
and has an improved safety profile compared to calcitriol.
Chemische Eigenschaften
Doxercalciferol is Crystalline Solid
Verwenden
Synthetic vitamin D prohormone. A new active Vitamin D analog which inhibits growth of human neuroblastoma.
Antihyperparathyroid
Biologische Aktivität
Vitamin D 2 analog that acts as a vitamin D receptor activator (VDRA).
Doxercalciferol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Doxercalciferol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 233)Lieferanten
54573-75-0()Verwandte Suche:
- 1-alpha-hydroxyergocalciferol
- 1alpha-hydroxyergocalciferol
- 1-alpha-hydroxyvitamind2
- 1-hydroxyergocalciferol
- 1ALPHA-OH-D2
- 7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5z,7e,22e)-10-secoergosta-5
- VITAMIN D2, 1ALPHA-HYDROXY-
- Vitamin D2, 1a-Hydroxy-
- (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-Dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
- Doxercalciferol
- 1A, 25-DIHYDROXYERGOCALCIFEROL
- 1A-HYDROXYERGOCALCIFEROL (NON GMP)
- ERCALCIDOL
- Doxecalciferol
- 4-Methylene-5-{2-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidene]-ethylidene}-cyclohexane-1,3-diol (1-alpha-Hydroxyvitamin D2)
- (1a,3,5Z,7E,22E)- 9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol1-Hydroxyergocalciferol
- 1a-Hydroxyergocalciferol
- 1a-Hydroxyvitamin D2
- 1-Hydroxy Vitamin D2
- 1-Hydroxyvitamin D2
- Hectorol
- TSA 840
- (1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyl-octahydroinden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
- (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1?,3?-diol
- (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol
- 1α-OHD2
- C08211
- 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
- (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
- (1S,3R,5Z,7E,22E)-9,10-Seco
- 4-methylene-5Z-[2E-[(1R,3aS)-octahydro-7aR-methyl-1R-[1R,4,5-trimethyl-2E-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3S-cyclohexanediol
- (1R,3S,E)-5-((E)-2-((1R,3AS,7aR)-1-((2R,5S,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyldihydro-1H-
- 1-alpha-Hydroxy Vitamin D2-d6
- Doxercalciferol d6
- Doxercalciferol / Ercalcidol
- Doxercalciferol CAS NO.54573-75-0 CAS NO.54573-75-0
- Doxercalcifero
- Vitamin D, 1α-Hydroxy- - CAS 54573-75-0 - Calbiochem
- (1S,3R,5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
- (5Z,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraene-1,3-diol
- 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
- 1α-Hydroxy Vitamin D2
- Hydroxyergocalciferol
- Doxercalciferol (1α-Hydroxyvitamin D2)
- Doxercalciferol D6Q: What is
Doxercalciferol D6 Q: What is the CAS Number of
Doxercalciferol D6 Q: What is the storage condition of
Doxercalciferol D6 Q: What are the applications of
Doxercalciferol D6
- DoxercalciferolQ: What is
Doxercalciferol Q: What is the CAS Number of
Doxercalciferol Q: What is the storage condition of
Doxercalciferol
- Doxercalciferol (1225601)
- (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-Dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
- 54573-75-0
- C28H44O2
- Inhibitors
- Vitamin D3 analogs
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- APIs
- 54573-75-0
