ChemicalBook >> CAS DataBase List >>Azacitidine
Azacitidine
- CAS No.
- 320-67-2
- Chemical Name:
- Azacitidine
- Synonyms
- AZACITIDINE;AZACYTIDINE;Vidaza;mylosar;5-AC;5 AZC;5-AZCR;5-AZAC;LADAKAMYCIN;5-Azacitidine
- CBNumber:
- CB00128416
- Molecular Formula:
- C8H12N4O5
- Molecular Weight:
- 244.2
- MDL Number:
- MFCD00006539
- MOL File:
- 320-67-2.mol
- MSDS File:
- SDS
Last updated:2024-03-16 17:09:04
| Melting point | 226-232 °C (dec.)(lit.) |
|---|---|
| alpha | 40 º (C=1, H2O 22 ºC) |
| Boiling point | 387.12°C (rough estimate) |
| Density | 1.4287 (rough estimate) |
| refractive index | 1.6590 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml). |
| pka | 13.46±0.70(Predicted) |
| form | lyophilized powder |
| color | White to Off-white |
| Water Solubility | 0.5-1.0 g/100 mL at 21 ºC |
| Merck | 14,887 |
| BRN | 620461 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| InChIKey | NMUSYJAQQFHJEW-WGDKFINWSA-N |
| LogP | -2.191 (est) |
| CAS DataBase Reference | 320-67-2(CAS DataBase Reference) |
| FDA UNII | M801H13NRU |
| NCI Dictionary of Cancer Terms | azacitidine; Vidaza |
| NCI Drug Dictionary | azacitidine |
| ATC code | L01BC07 |
| Proposition 65 List | Azacitidine |
| IARC | 2A (Vol. 50) 1990 |
| EPA Substance Registry System | Azacitidine (320-67-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H341-H350-H360FD-H372-H410 | |||||||||
| Precautionary statements | P202-P260-P264-P273-P301+P312-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-46-22 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XZ3017500 | |||||||||
| F | 10-23 | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 115.9 i.p.; 572.3 orally (Palm, Kensler) | |||||||||
| NFPA 704 |
|
Azacitidine price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1287 | 5-Azacytidine Hybri-Max?, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma | 320-67-2 | 1vial | $29.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1045520 | Azacitidine United States Pharmacopeia (USP) Reference Standard | 320-67-2 | 150mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | A2033 | 5-Azacytidine >98.0%(T) | 320-67-2 | 1g | $202 | 2024-03-01 | Buy |
| TCI Chemical | A2033 | 5-Azacytidine >98.0%(T) | 320-67-2 | 100mg | $39 | 2024-03-01 | Buy |
| Alfa Aesar | J64159 | 5-Azacytidine, 98% | 320-67-2 | 1g | $63.65 | 2024-03-01 | Buy |
Azacitidine Chemical Properties,Uses,Production
Uses
Azacitidine is a demethylating agent chemotherapeutic agent used to treat chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemia (AML) and myelodysplastic syndromes.
Mechanism of action
Azacitidine, a chemical analogue of cytidine, is incorporated into DNA and RNA and produces cytotoxic effects on haematopoietic cells in the bone marrow at high doses. Azacitidine is incorporated into RNA in greater amounts than DNA, and the incorporation of azacitidine into RNA results in the breakdown of polysomes, accumulation of 80S ribosomes, decreased activity of transfer RNA receptors, and inhibition of protein synthesis. At low doses, azacitidine inhibits DNA methyltransferase by forming a covalent bond between DNA-cytosine methyltransferase and 5-azacytosine-containing DNA, resulting in DNA hypomethylation.
Side effects
Azacitidine is usually given by injection and its side effects include: diarrhoea, loss of appetite, dizziness, bone pain, bruising, chest pain, headache, bleeding gums, skin lumps, dry skin, chills, cough, measles, loss of appetite, pain in the bladder, bleeding after having a bowel movement, constipation, fast heartbeat or feeling unwell, fever, fatigue, cloudy urine, difficulty breathing and swallowing. It varies from person to person and not all of the above symptoms may occur.
Azacitidine Preparation Products And Raw materials
Global( 651)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1642 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12470 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6011 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | daisy@crovellbio.com | China | 5956 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15954 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9340 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
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- 5-Azacytidine (NSC-102816), 4-amino-1-β-d-ribofuranosyl-1,3,5-triazine- 2(1H)-one, 5-azacitidine, C8H12N4O5, Mr 244.21, is a p....
- Mar 16，2024
View Lastest Price from Azacitidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-11 | Azacitidine Impurity 27 | US $0.00-0.00 / mg | 1mg | above 96% | 50mg | Guangzhou Tosun Pharmaceutical Limited | |
 |
2024-03-12 | Azacitidine
320-67-2
|
US $0.00 / g | 1g | 98% HPLC | 100kg | shandong perfect biotechnology co.ltd |
-
- Azacitidine Impurity 27
- US $0.00-0.00 / mg
- above 96%
- Guangzhou Tosun Pharmaceutical Limited
-
- Azacitidine
320-67-2
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd
320-67-2(Azacitidine)Related Search:
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Azacytidine-15N4
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LedakaMycin-15N4
Mylosar-15N4
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U 18496-15N4
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