(-)-ANABASINE
- CAS No.
- 494-52-0
- Chemical Name:
- (-)-ANABASINE
- Synonyms
- Anabasin;Anabazin;ANOBASINE;ANABASINE;Neonikoti;Neonikotin;NEONICOTINE;L-ANABASINE;(-)-anabasin;(-)-ANABASINE
- CBNumber:
- CB0119964
- Molecular Formula:
- C10H14N2
- Molecular Weight:
- 162.23
- MDL Number:
- MFCD00871391
- MOL File:
- 494-52-0.mol
- MSDS File:
- SDS
Melting point | 9°C |
---|---|
Boiling point | 270-272°C |
alpha | D20 -83.1° |
Density | 1,0455 g/cm3 |
refractive index | 1.5430 |
Flash point | 93°C |
storage temp. | 2-8°C |
solubility | DMSO : 100 mg/mL (616.41 mM) |
pka | 8.98±0.10(Predicted) |
form | Liquid |
Merck | 14,619 |
BRN | 82637 |
CAS DataBase Reference | 494-52-0(CAS DataBase Reference) |
FDA UNII | LMS11II2LO |
NIST Chemistry Reference | Pyridine, 3-(2-piperidinyl)-, (S)-(494-52-0) |
EPA Substance Registry System | Anabasine (494-52-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS09,GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H310-H411-H300 |
Precautionary statements | P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
Hazard Codes | T |
Risk Statements | 27/28-51/53-23/24/25 |
Safety Statements | 28-36/37-45-61-36/37/39-28A |
RIDADR | 3140 |
RTECS | BV4375000 |
HazardClass | 6.1 |
PackingGroup | I |
HS Code | 29333990 |
Toxicity | LDLo orl-dog: 50 mg/kg JPETAB 48,95,33 |
(-)-ANABASINE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A637170 | (S)-Anabasine,>98%ee | 494-52-0 | 100mg | $350 | 2021-12-16 | Buy |
TRC | A637170 | (S)-Anabasine,>98%ee | 494-52-0 | 500mg | $1455 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | HBL0000006 | (-)-ANABASINE 95.00% | 494-52-0 | 1G | $1593.9 | 2021-12-16 | Buy |
Activate Scientific | AS7078-A | (S)-3-(Piperidin-2-yl)pyridine 95+% ee | 494-52-0 | 5G | $2356 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA17898 | (S)-Anabasine | 494-52-0 | 500mg | $675 | 2021-12-16 | Buy |
(-)-ANABASINE Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Oil
Uses
(S)-ANABASINE is used as a kind of Nicotinic receptor agonist.
Uses
Anabasine occurs in the tobacco speciesNicotiana glauca, Anabasis aphylla L.,Chenopodiaceae, and Solanaceae. It is usedas an insecticide and as a metal anticorrosiveagent.
Definition
ChEBI: The (S)-enantiomer of anabasine.
Health Hazard
The acute toxic symptoms include increasedsalivation, confusion, disturbed vision, photophobia,nausea, vomiting, diarrhea, respiratorydistress, and convulsions. It causesrespiratory muscle stimulation similar to thatcaused by lobeline. An oral lethal dose indogs is 50 mg/kg. A subcutaneous lethaldose in guinea pigs is 10 mg/kg.
Biological Activity
Anabasine ((S)-Anabasine) is an alkaloid, a component of tobacco. Anabasine is a botanical insecticide that acts as a pan-agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization in TE671 cells endogenously expressing human myogenic nAChRs (EC50=0.7 μM).
Safety Profile
Poison by ingestion,subcutaneous, and intravenous routes. Moderately toxicby skin contact. An experimental teratogen. Insecticide.Acute and subacute toxicity: increased salivation, vertigo,confusion, disturbed vision and hearing, photophobia,cold ext
in vivo
Anabasine significantly reverses the impairment at the 0.2 mg/kg (p<0.05) and 2 mg/kg doses (p<0.025). Anabasine does not have any significant effects on response latency when administered alone. The 0.06 mg/kg Anabasine dose, in fact, significantly (p<0.05) exacerbates the dizocilpine-induced impairment. None of these Anabasine doses affects choice accuracy on their own. Individual dose comparisons show that the 0.06 mg/kg Anabasine dose plus dizocilpine (6.7±2.6) causes a significant (p<0.05) increase in non-response trials compare with dizocilpine alone (2.1±0.8).
(-)-ANABASINE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13039 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from (-)-ANABASINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-01-12 | Anabasine
494-52-0
|
US $1.00-90.00 / KG | 0.5KG | >99% | 20tons | Anhui Rencheng Technology Co., Ltd | ||
2021-08-11 | (-)-ANABASINE
494-52-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2020-03-06 | Anabasine
494-52-0
|
US $8.00 / KG | 1g | ≥98% | kg--tons | Career Henan Chemical Co |
- Anabasine
494-52-0
- US $1.00-90.00 / KG
- >99%
- Anhui Rencheng Technology Co., Ltd
- (-)-ANABASINE
494-52-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Anabasine
494-52-0
- US $8.00 / KG
- ≥98%
- Career Henan Chemical Co
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