Dothiepin
- CAS No.
- 113-53-1
- Chemical Name:
- Dothiepin
- Synonyms
- iz914;Dothep;IZ 914;dosulepin;Methiaden;DOTHIEPIN;Dosulepine;Prothiaden;Prothiadene;Dolsulepine
- CBNumber:
- CB0378413
- Molecular Formula:
- C19H21NS
- Molecular Weight:
- 295.44
- MDL Number:
- MFCD00242922
- MOL File:
- 113-53-1.mol
| Melting point | 55-57° |
|---|---|
| Boiling point | bp0.05 171-172° |
| Density | 1.1022 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Thick Oil to Low-Melting Solid |
| pka | 9.35±0.28(Predicted) |
| color | Off-White to Light Yellow |
| EWG's Food Scores | 1 |
| FDA UNII | W13O82Z7HL |
| ATC code | N06AA16 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H361-H362 |
| Precautionary statements | P201-P260-P263-P264-P280-P308+P313 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 oral in rat: 450mg/kg |
Dothiepin price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001965 | Dosulepin for system suitability European Pharmacopoeia (EP) Reference Standard | 113-53-1 | Y0001965 | $147 | 2023-01-07 | Buy |
| TRC | D536500 | Dothiepin | 113-53-1 | 50mg | $1355 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007912 | DOSULEPIN 95.00% | 113-53-1 | 2MG | $300 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 9808 | Dothiepin | 113-53-1 | 5mg | $490 | 2021-12-16 | Buy |
Dothiepin Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Low Melting Solid
History
Described in the 1960s by the Czech company Sdruzeni Podniku pro Zdravotnickon Vyrobu; SPOFA (Spofa, 1962)
Uses
A tricyclic antidepressant.
Definition
ChEBI: Dothiepin is a dibenzothiepine. It has a role as an antidepressant and an anticoronaviral agent.
Synthesis Reference(s)
Synthesis (Spofa, 1962): S-Benzylthiosalicylic acid is treated with polyphosphoric acid and the resulting cyclic ketone is reacted with 3-dimethylaminopropyl magnesium chloride to afford an alcohol which is dehydrated with sulfuric acid. 
Synthesis of dosulepin
Clinical Use
Dosulepin (also referred to as dothiepin) is a member of the TCA family and has similar clinical uses as amitrip- tyline, thus providing effective treatment of depression (Goldstein and Claghorn, 1980; Lancaster and Gonzales, 1989; Donovan et al., 1991) and also against pain (Feinmann et al., 1984; Caruso et al., 1987) and tinnitus. Like amitriptyline it has sedative properties, however its anti-muscarinic side-effects are less pronounced. Dosulepin is readily absorbed from the GI tract and extensively demethylated while undergoing a first-pass effect. Metabolic pathways include next to hydroxylation and N-oxidation steps, S-oxidation. Elimination half-lifes vary from 14 to 24 hours interindividually (Maguire et al., 1982; Yu et al., 1986; Ilett et al., 1993).
Dothiepin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
| Hebei Duling International Trade Co. LTD | +8618712993135 | sales01@hbduling.cn | China | 15738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Chengdu Dianchun Technology Co., Ltd | 400-1166-196 18502815961 | cdhxsj@163.com | China | 14623 | 60 |
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