iproniazid
- CAS No.
- 54-92-2
- Chemical Name:
- iproniazid
- Synonyms
- IPRAZID;Marsilid;iproniazid;Iproniazid>n’-isopropylisonicotinohydrazide;1-Isonicotinoyl-2-isopropylhydrazine;N'-Isopropylpyridine-4-Carbohydrazide;Isonicotinic Acid 2-Isopropylhydrazide;N'-propan-2-ylpyridine-4-carbohydrazide;Isonicotinic acid N'-isopropyl-hydrazide
- CBNumber:
- CB0928533
- Molecular Formula:
- C9H13N3O
- Molecular Weight:
- 179.22
- MDL Number:
- MFCD00153819
- MOL File:
- 54-92-2.mol
- MSDS File:
- SDS
| Melting point | 112.5-113.5° |
|---|---|
| Boiling point | 311.75°C (rough estimate) |
| Density | 1.1305 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 11.28±0.23(Predicted) |
| color | Pale Beige |
| CAS DataBase Reference | 54-92-2 |
| FDA UNII | D892HFI3XA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P501-P270-P264-P301+P312+P330 |
| HS Code | 2933399990 |
| Toxicity | An isopropyl derivative of isoniazid that was found to have mood-elevating effects in tuberculosis patients. It was later found to be a monoamine oxidase (MAO) inhibitor and, although not currently approved for clinical use as an antidepressant due to its propensity to cause liver damage it led to the development of other MAO inhibitors currently in use. In addition to hepatotoxic effects, iproniazid is a hypotensive agent and can cause potentially hazardous reactions with other drugs and amine-rich foods. |
iproniazid price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I746500 | Iproniazid | 54-92-2 | 5g | $1110 | 2021-12-16 | Buy |
| Usbiological | 014945 | Iproniazid | 54-92-2 | 500mg | $446 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59217 | Iproniazid | 54-92-2 | 500mg | $640 | 2021-12-16 | Buy |
| Matrix Scientific | 145053 | N'-Isopropylisonicotinohydrazide 95% | 54-92-2 | 5g | $1601 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59217 | Iproniazid | 54-92-2 | 5G | $2120 | 2021-12-16 | Buy |
iproniazid Chemical Properties,Uses,Production
Originator
Marsilid,Roche,US,1952
Uses
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.
Definition
ChEBI: Iproniazid is a carbohydrazide and a member of pyridines.
Manufacturing Process
A mixture of 40 g of isonicotinyl hydrazine and 600 cc of acetone was heated
on a steam bath until solution was complete. Upon cooling the reaction
mixture, 1-isonicotinyl-2-isopropylidene hydrazine precipitated in the form of
white needles; MP 161°C to 161.5°C.
A solution of 20 g of 1-isonicotinyl-2-isopropylidene hydrazine in 150 cc of
methanol was reduced with hydrogen at room temperature and 50 psi using
300 mg of platinum black as a catalyst.
brand name
Euphozid;Ipropran;Isotamine;Laniazid;Marsilid;Nydrazid;P-1-n forte;Pms isoniazid;Rifamate;Rimactane;Rimifon;Ro 7-1554;Teebaconin;Triniad;Uniad.
Therapeutic Function
Antidepressant, Monoamine oxidase inhibitor
World Health Organization (WHO)
Iproniazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1952 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus iproniazid remains available in several countries.
Purification Methods
Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9634 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13040 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6856 | 58 |
View Lastest Price from iproniazid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-19 | iproniazid
54-92-2
|
US $0.00 / KG | 1KG | 99.5% | 100 tons | Honest Joy Holdings Limited
|
|
 |
2020-01-19 | iproniazid
54-92-2
|
US $1.00 / KG | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
-
- iproniazid
54-92-2
- US $0.00 / KG
- 99.5%
- Honest Joy Holdings Limited
-
- iproniazid
54-92-2
- US $1.00 / KG
- 99.0%
- Career Henan Chemical Co
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