ChemicalBook >> CAS DataBase List >>2'-DEOXY-5-FLUOROCYTIDINE

2'-DEOXY-5-FLUOROCYTIDINE

2'-DEOXY-5-FLUOROCYTIDINE structure

CAS No.: 10356-76-0

Chemical Name:: 2'-DEOXY-5-FLUOROCYTIDINE

Synonyms: FCDR;FdCyd;5--F-dC;NSC 48006;Ro 5-1090;5-F-2'-dC;5-Fluoro-2;5-F-2'-deoxycytidine;5-fluorodeoxycytidine;5-fluor-desoxycytidin

CBNumber:: CB1122369

Molecular Formula:: C9H12FN3O4

Molecular Weight:: 245.21

MDL Number:: MFCD00077348

MOL File:: 10356-76-0.mol

MSDS File:: SDS

Last updated:2023-10-19 16:57:28

Request For Quotation

2'-DEOXY-5-FLUOROCYTIDINE Properties

Melting point	196 °C
Boiling point	465℃
Density	1.82
refractive index	70 ° (C=1, H2O)
Flash point	235℃
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: >20mg/mL
form	powder
pka	14.03±0.60(Predicted)
color	white to off-white
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
CAS DataBase Reference	10356-76-0(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	5-fluoro-2-deoxycytidine; FdCyd
FDA UNII	KUA4693H5W
NCI Drug Dictionary	5-fluoro-2-deoxycytidine
EPA Substance Registry System	5-Fluoro-2'-deoxycytidine (10356-76-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P261-P280-P305+P351+P338

Hazard Codes

Risk Statements

WGK Germany

RTECS

HA3850000

HS Code

2940.00.6000

NFPA 704

	0
2		0

2'-DEOXY-5-FLUOROCYTIDINE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F5307	5?Fluoro?2′?deoxycytidine ≥98% (HPLC), powder	10356-76-0	5mg	$43.2	2024-03-01	Buy
Sigma-Aldrich	F5307	5?Fluoro?2′?deoxycytidine ≥98% (HPLC), powder	10356-76-0	25mg	$419	2024-03-01	Buy
TCI Chemical	D3642	2'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T)	10356-76-0	1g	$274	2024-03-01	Buy
TCI Chemical	D3642	2'-Deoxy-5-fluorocytidine >98.0%(HPLC)(T)	10356-76-0	5g	$822	2023-06-20	Buy
TRC	F590803	5-Fluoro-2''-deoxycytidine	10356-76-0	5mg	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
F5307	5mg	$43.2	Buy
F5307	25mg	$419	Buy
D3642	1g	$274	Buy
D3642	5g	$822	Buy
F590803	5mg	$60	Buy

2'-DEOXY-5-FLUOROCYTIDINE Chemical Properties,Uses,Production

Description

5-Fluoro-2-Deoxycytidine is an antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.

Uses

5-Fluoro-2''-deoxycytidine is a mechanism-based DNMT inhibitor.

Uses

5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others.

General Description

Fine white powder.

Air & Water Reactions

2'-DEOXY-5-FLUOROCYTIDINE is probably light and air sensitive.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 2'-DEOXY-5-FLUOROCYTIDINE emits toxic fumes of fluoride ion and NOx.

Fire Hazard

Flash point data for 2'-DEOXY-5-FLUOROCYTIDINE are not available. 2'-DEOXY-5-FLUOROCYTIDINE is probably combustible.

Pharmacology

5-Fluoro-2'-deoxycytidine (FdCyd), a fluoropyrimidine nucleoside analog, has a short (10-minute) half-life and is rapidly degraded in vivo by cytidine deaminase. However, coadministration with tetrahydrouridine (THU), an inhibitor of cytidine/deoxycytidine deaminase, has been shown to increase the AUC of the parent compound more than 4-fold. Increased FdCyd exposure allows it to be taken up intracellularly and converted to its triphosphate, which is incorporated into DNA and inhibits the action of the enzyme DNA methyltransferase (DNMT). Inhibition of DNMT, and in turn DNA methylation, can result in the re-expression of tumor suppressor genes.
Primary objective:
-Determine progression-free survival (PFS) and/or the response rate (CR + PR) of FdCyd administered 5 days per week for 2 weeks, in 28-day cycles, by intravenous infusion over 3 hours along with THU in patients with breast cancer, head and neck cancer, non-small cell lung cancer, and urothelial transitional cell carcinoma.
Exploratory objectives:
Evaluate whether treatment with FdCyd and THU alters DNA methylation patterns in tumor biopsy samples before and during treatment by LINE-1 analysis.
Evaluate the safety and tolerability of FdCyd (100 mg/m(2)) + THU (350 mg/m(2)) administered 5 days per week for 2 weeks, in 28-day cycles, by intravenous infusion over 3 hours.
Measure changes in the number of CTCs following treatment with FdCyd plus THU.

Clinical Use

A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo.

References

1) Ren?et al. (2011),?DNA hypermethylation as a chemotherapy target; Cell Signal,?23?1082 2) Gowher?et al. (2004),?Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy; Cancer Biol. Ther.,?3?1062 3) Zhao?et al. (2002),?Inhibition of cancer cell proliferation by 5-fluoro-2′-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway; Springerplus,?1?65 4) Kumaki?et al. (2001),?In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections; Antiviral Res.,?92?329

2'-DEOXY-5-FLUOROCYTIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

2'-DEOXY-5-FLUOROCYTIDINE Suppliers

Global( 152)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6008	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Yunbio Tech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
Antai Fine Chemical Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 2'-DEOXY-5-FLUOROCYTIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-10-19	2'-Deoxy-5-fluorocytidine 10356-76-0	US $30.00-10.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.
2023-10-11	2'-DEOXY-5-FLUOROCYTIDINE 10356-76-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-06	2'-Deoxy-5-fluorocytidine 10356-76-0	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

2'-Deoxy-5-fluorocytidine
10356-76-0
US $30.00-10.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

2'-DEOXY-5-FLUOROCYTIDINE
10356-76-0
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2'-Deoxy-5-fluorocytidine
10356-76-0
US $30.00-10.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

2'-DEOXY-5-FLUOROCYTIDINE Spectrum

2'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)MS 2'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)IR1 2'-DEOXY-5-FLUOROCYTIDINE(10356-76-0)IR2

10356-76-0(2'-DEOXY-5-FLUOROCYTIDINE)Related Search:

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine Dmt-2'-f-dc(ac) amidite N-(3,4,5-Trimethoxybenzoyl)-5'-deoxy-5-fluorocytidine Gemcitabine 2'-Fluoro-N4-Acetyl-5'-O-DMT-2'-deoxycytidine

5-Fluorocytidine 2'-Deoxy-2'-fluorocytidine Hydrate,2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'- DEOXYCYTIDINE, 2'-FC),2''-DEOXY-2''-FLUOROCYTIDINE,99+%,2'-DEOXY-2'-FLUOROCYTIDINE 2'-Fluoro-N4-Benzoyl-5'-O-DMT-2'-deoxycytidine N4-Acetyl-2'-Fluoro-2'-deoxycytidine 2'-DEOXY-5-FLUOROCYTIDINE

5'-DEOXY-5-FLUOROCYTIDINE,5''-DEOXY-5-FLUOROCYTIDINE (5''-DFCR) N4-Benzoyl-2'-Fluoro-2'-deoxycytidine 2',3',5'-TRI-O-BENZOYL-5-FLUOROURIDINE-13C,15N2 5-Fluoro-2',3'-O-isopropylidene-D-cytidine 5'-DEOXY-5-FLUOROCYTIDINE-13C,15N2

2',3'-DI-O-ACETYL-5'-DEOXY-5-FLUOROCYTIDINE 3'-Deoxy-3'-fluorocytidine 5'-O-(4,4'-Dimethoxytrityl)-N-acetyl-2'-deoxy-2'-fluorocytidine

1of4

2'-DEOXY-5-FLUOROCYTIDINE 2’-deoxy-5-fluoro-cytidin 5-FLUORO-2'-DEOXYCYTIDINE 5-fluor-desoxycytidin 5-fluorodeoxycytidine 5--F-dC 2′-deoxy-5-fluoroCytidine\5-Fluoro-2′-deoxycytidine 4-AMino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one Cytidine,2'-deoxy-5-fluoro- FCDR FdCyd 5-F-2'-deoxycytidine 5-Fluoro-2 NSC 48006 Ro 5-1090 5-F-2'-dC 2'-Deoxy-5-fluorocytidine> -Deoxy-5-fluorocytidine 5-Fluoro-2'-deoxycytidine 2'-Deoxy-5-fluorocytidine 10356-76-0 Biochemistry Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents Nucleosides-5-F Nucleosides