N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- CAS No.
- 1477-57-2
- Chemical Name:
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- Synonyms
- SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine
- CBNumber:
- CB2146249
- Molecular Formula:
- C12H20Cl4N2O2
- Molecular Weight:
- 366.11
- MDL Number:
- MFCD00000841
- MOL File:
- 1477-57-2.mol
- MSDS File:
- SDS
| Melting point | 118-120 °C |
|---|---|
| Boiling point | 530℃ |
| Density | 0.726 |
| refractive index | 1.6200 (estimate) |
| Flash point | 275℃ |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated |
| pka | 12.28±0.46(Predicted) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 1477-57-2 |
| FDA UNII | 3F56RA64JN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312+H332-H351 | |||||||||
| Precautionary statements | P202-P261-P280-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 24/25-45-36 | |||||||||
| Toxicity | LD50 orally in mice: >16000 mg/kg (Coulston) | |||||||||
| NFPA 704 |
|
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3187 | WIN 18446 ≥98% (HPLC) | 1477-57-2 | 50MG | $123 | 2024-03-01 | Buy |
| Cayman Chemical | 14018 | WIN 18,446 ≥98% | 1477-57-2 | 50mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14018 | WIN 18,446 ≥98% | 1477-57-2 | 100mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 14018 | WIN 18,446 ≥98% | 1477-57-2 | 250mg | $151 | 2024-03-01 | Buy |
| Tocris | 4736 | WIN18446 | 1477-57-2 | 50 | $125 | 2021-12-16 | Buy |
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Win 18446 was shown to inhibit the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis and in the embryonic murine gonad.
Definition
ChEBI: A carboxamide that is 1,8-diaminooctane in which a hydrogen attached to each of the amino groups has been replaced by a dichloroacetyl group. Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2). Inhibits the biosynthesis of retinoic acid from retinol in neon tal and adult murine testis. It down-regulates sex related genes in zebrafish.
Biological Activity
win 18446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2 (aldh1a2), with ic50 value of 300 nm [1].aldh1a2, expressed almost exclusively in the testes, localizes to developing germ cells within the seminiferous tubules and strongly binds retinol, but does not recognize acetaldehyde as a substrate, suggesting that aldh1a2 functions in testicular retinoic acid biosynthesis [1].in whole testes or germ cells isolated from mice at 2 days postpartum, win 18,446 alone (1 μm) or in combination with retinol significantly reduced the expression of stra8, a marker for retinoic acid activity [2].in male rabbits, oral administration of win 18446 at 200 mg/kg for 16 weeks substantially reduced intratesticular concentrations of retinoic acid, significantly impaired spermatogenesis, and resulted in infertility. reduced concentrations of intratesticular retinoic acid became obvious after only 4 weeks of treatment and preceded the decrease in sperm counts and the loss of mature germ cells in tissue samples. sperm counts and fertility recovered after treatment was discontinued [1].[1]. amory j k, muller c h, shimshoni j a, et al. suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. journal of andrology, 2011, 32(1): 111-119.[2]. hogarth c a, evanoff r, snyder e, et al. suppression of stra8 expression in the mouse gonad by win 18,446. biology of reproduction, 2011, 84(5): 957-965.
Safety Profile
Poison by intraperitoneal route.Human systemic effects by ingestion: nausea andvomiting. Human reproductive effects by ingestion:changes in spermatogenesis. An experimental teratogen.Other experimental reproductive effects. Human mutationdata reporte
storage
Store at +4°C
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Preparation Products And Raw materials
Raw materials
Preparation Products
N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9635 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3725 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
1477-57-2(N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE))Related Search:
1of4